患有孕前糖尿病的女性所生男婴围产期结局较差。

Poorer perinatal outcome in male newborns of women with pregestational diabetes mellitus.

机构信息

Servei d'Endocrinologia i Nutrició Servei de Pediatria Servei de Ginecologia i Obstetricia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

出版信息

Diabet Med. 2011 Apr;28(4):436-9. doi: 10.1111/j.1464-5491.2011.03227.x.

DOI:10.1111/j.1464-5491.2011.03227.x

PMID:21392065

Abstract

AIMS

To assess perinatal outcome in women with pregestational diabetes mellitus according to the sex of the fetus.

METHODS

A retrospective review of all singleton pregnancies of women with pregestational diabetes progressing to a gestational age of 22 weeks or more who attended the diabetes and pregnancy clinic from 1981 to 2006 (n=455). We compared maternal characteristics and perinatal outcomes (perinatal mortality, major congenital malformations, small and large for gestational age newborns, preterm birth and a composite of the former) according to the sex of the fetus. A logistic regression analysis was performed using the composite perinatal outcome as the dependent variable and all maternal variables and sex of fetus as potential predictors.

RESULTS

Maternal characteristics did not differ in mothers of male and female newborns. In the whole cohort, the composite perinatal outcome was significantly higher in male fetuses; adjusted OR 1.61 (95% CI 1.04-2.50).

CONCLUSIONS

In women with pregestational diabetes, perinatal outcome was poorer in male newborns despite similar maternal characteristics.

摘要

目的

根据胎儿性别评估患有孕前糖尿病的女性的围产期结局。

方法

对 1981 年至 2006 年期间在糖尿病和妊娠诊所就诊的所有进展至 22 周或以上妊娠龄的、患有孕前糖尿病的单胎妊娠女性（n=455）进行回顾性研究。我们比较了胎儿性别不同的女性的母体特征和围产期结局（围产儿死亡率、主要先天畸形、小于胎龄儿和大于胎龄儿、早产以及上述情况的综合）。使用复合围产儿结局作为因变量，所有母体变量和胎儿性别作为潜在预测因子，进行逻辑回归分析。