Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece.
J Hosp Infect. 2011 Jul;78(3):171-7. doi: 10.1016/j.jhin.2010.12.006. Epub 2011 Mar 9.
We reviewed the effectiveness of airborne hydrogen peroxide as an environmental disinfectant and infection control measure in clinical settings. Systematic review identified ten studies as eligible for inclusion. Hydrogen peroxide was delivered in the form of vapour and dry mist in seven and three studies, respectively. Pathogens evaluated included meticillin-resistant Staphylococcus aureus (MRSA), Clostridium difficile and multiple bacterial types, in five, three, and two studies, respectively. Before the application of any cleaning intervention, 187/480 (39.0%; range: 18.9-81.0%) of all sampled environmental sites were found to be contaminated by the studied pathogens in nine studies that reported specific relevant data. After application of terminal cleaning and airborne hydrogen peroxide, 178/630 (28.3%; range: 11.9-66.1%) of the sampled sites in six studies and 15/682 (2.2%; range: 0-4.0%) of the sampled sites in ten studies, respectively, remained contaminated. Four studies evaluated the use of hydrogen peroxide vapour for infection control. This was associated with control of a nosocomial outbreak in two studies, eradication of persistent environmental contamination with MRSA and decrease in C. difficile infection in each of the remaining two studies.
我们回顾了空气过氧化氢作为临床环境消毒剂和感染控制措施的有效性。系统评价确定了 10 项符合纳入标准的研究。过氧化氢分别以蒸气和干雾的形式在 7 项和 3 项研究中使用。评估的病原体包括耐甲氧西林金黄色葡萄球菌（MRSA）、艰难梭菌和多种细菌类型，分别在 5、3 和 2 项研究中。在进行任何清洁干预之前，在 9 项报告了具体相关数据的研究中，有 187/480（39.0%；范围：18.9-81.0%）的所有环境采样点被研究病原体污染。在进行终末清洁和空气过氧化氢处理后，在 6 项研究中有 178/630（28.3%；范围：11.9-66.1%）的采样点和 10 项研究中有 15/682（2.2%；范围：0-4.0%）的采样点仍然受到污染。有 4 项研究评估了过氧化氢蒸气在感染控制中的应用。这与 2 项研究中控制医院感染暴发、根除 MRSA 持续环境污染和减少艰难梭菌感染有关。
