Department of Neuroscience and Imaging, University "G. d'Annunzio" Chieti-Pescara, Italy.
AJNR Am J Neuroradiol. 2011 Jun-Jul;32(6):1056-64. doi: 10.3174/ajnr.A2428. Epub 2011 Mar 10.
An alternative technique, which is less influenced by tumor- and patient-related factors, is required to overcome the limits of GLM analysis of fMRI data in patients. The aim of this study was to statistically assess differences in the identification of language regions and hemispheric lateralization of language function between controls and patients as estimated by both the GLM and a novel combined ICA-GLM procedure.
We retrospectively evaluated 42 patients with pathologically confirmed brain gliomas of the left frontal and/or temporoparietal lobes and a control group of 14 age-matched healthy volunteers who underwent BOLD fMRI to lateralize language functions in the cerebral hemispheres. Data were processed by using a classic GLM and ICA-GLM.
ICA-GLM demonstrated a higher sensitivity in detecting language activation, specifically in the left TPJ of patients. There were no significant differences between the GLM and ICA-GLM in controls; however, statistically significant differences were observed by using ICA-GLM for the LI in patients. For the computation of the LI, ICA-GLM was less influenced by the chosen statistical threshold compared with the GLM.
We suggest the use of the ICA-GLM as a valid alternative to the classic GLM method for presurgical mapping in patients with brain tumors and to replicate the present results in a broader sample of patients.
为了克服 fMRI 数据 GLM 分析在患者中的局限性，需要一种受肿瘤和患者相关因素影响较小的替代技术。本研究旨在通过 GLM 和一种新的联合 ICA-GLM 方法，从统计学上评估在识别语言区域和语言功能的半球侧化方面，控制组和患者组之间的差异。
我们回顾性评估了 42 例经病理证实的左额和/或颞顶叶脑胶质瘤患者和 14 名年龄匹配的健康志愿者的对照组成员，他们接受了 BOLD fMRI 以确定大脑半球的语言功能侧化。数据通过经典 GLM 和 ICA-GLM 进行处理。
ICA-GLM 检测语言激活的敏感性更高，特别是在患者的左侧 TPJ。在对照组中，GLM 和 ICA-GLM 之间没有显著差异；然而，对于患者的 LI，使用 ICA-GLM 观察到了统计学上的显著差异。对于 LI 的计算，ICA-GLM 受所选统计阈值的影响小于 GLM。
我们建议使用 ICA-GLM 作为经典 GLM 方法的有效替代方法，用于脑肿瘤患者的术前定位，并在更广泛的患者样本中复制本研究的结果。
