Institute for Advanced Biomedical Technologies, G D'Annunzio University Foundation, Chieti, Italy.
PLoS One. 2012;7(7):e40231. doi: 10.1371/journal.pone.0040231. Epub 2012 Jul 9.
The aim of the study was to evaluate connectivity modifications in the Default Mode Network (DMN) in patients with cerebral glioma, and to correlate these modifications to tumor characteristics.
Twenty-four patients with a left-hemisphere cerebral tumor (14 grade II and 10 grade IV gliomas) and 14 healthy age-matched right-hand volunteers were enrolled in the study. Subjects underwent fMRI while performing language tasks for presurgical mapping. Data was analyzed with independent component analysis in order to identify the DMN. DMN group maps were produced by random-effect analysis (p<0.001, FDR-corrected). An analysis of variance across the three groups (p<0.05) and post-hoc t-test contrasts between pairs of groups were calculated (p<0.05, FDR-corrected).
All three groups showed typical DMN areas. However, reduced DMN connectivity was detected in tumor patients with respect to controls. A significantly increased and reduced integration of DMN areas was observed in the hippocampal and prefrontal regions, respectively. Modifications were closely related to tumor grading. Moreover, the DMN lateralized to the hemisphere contralateral to tumor in the low-grade, but not in the high-grade tumor patients.
Modifications of DMN connectivity were induced by gliomas and differed for high and low grade tumors.
本研究旨在评估脑胶质瘤患者的默认模式网络（DMN）的连接变化，并将这些变化与肿瘤特征相关联。
本研究纳入了 24 名左侧大脑肿瘤患者（14 级 II 级和 10 级 IV 级胶质瘤）和 14 名年龄匹配的右利手健康志愿者。受试者在进行语言任务进行术前定位时接受 fMRI 检查。使用独立成分分析对数据进行分析，以确定 DMN。通过随机效应分析（p<0.001，FDR 校正）生成 DMN 组图。对三组之间的方差分析（p<0.05）和两组之间的事后 t 检验对比（p<0.05，FDR 校正）进行了计算。
所有三组均显示出典型的 DMN 区域。然而，与对照组相比，肿瘤患者的 DMN 连接减少。在海马和前额叶区域分别观察到 DMN 区域的整合增加和减少。这些变化与肿瘤分级密切相关。此外，在低级别肿瘤患者中，DMN 偏向于肿瘤对侧的半球，但在高级别肿瘤患者中则没有。
DMN 连接的改变是由胶质瘤引起的，并且在高级别和低级别肿瘤之间存在差异。
