Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, CA 92037, USA.
Eur J Neurosci. 2011 Mar;33(6):1160-9. doi: 10.1111/j.1460-9568.2011.07615.x.
Adult neurogenesis is a sophisticated biological process whose function has remained a mystery to neuroscience researchers. To address this question, a number of unique modeling studies have explored the computational implications of adding new neurons to the adult dentate gyrus. Models of neurogenesis fall into two broad categories: abstract models that explore the function of new neurons in simple networks, and biologically based models that investigate the role of new neurons in networks based on the anatomy of the hippocampus. In this review, we summarize the strategies and results of these different modeling approaches, and we discuss their conclusions and limitations in the face of new biological findings.
成人神经发生是一个复杂的生物学过程，其功能一直是神经科学研究人员的一个谜。为了解决这个问题，许多独特的建模研究探索了向成年齿状回添加新神经元的计算意义。神经发生模型分为两类：抽象模型，探索新神经元在简单网络中的功能；基于生物学的模型，研究新神经元在基于海马体解剖结构的网络中的作用。在这篇综述中，我们总结了这些不同建模方法的策略和结果，并讨论了它们在面对新的生物学发现时的结论和局限性。
