TGF-β 信号在腭发育过程中的作用机制。
The mechanism of TGF-β signaling during palate development.
机构信息
Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA.
出版信息
Oral Dis. 2011 Nov;17(8):733-44. doi: 10.1111/j.1601-0825.2011.01806.x. Epub 2011 Mar 13.
Abstract
Cleft palate, a malformation of the secondary palate development, is one of the most common human congenital birth defects. Palate formation is a complex process resulting in the separation of the oral and nasal cavities that involves multiple events, including palatal growth, elevation, and fusion. Recent findings show that transforming growth factor beta (TGF-β) signaling plays crucial roles in regulating palate development in both the palatal epithelium and mesenchyme. Here, we highlight recent advances in our understanding of TGF-β signaling during palate development.
摘要
腭裂，一种继发腭发育畸形，是最常见的人类先天性出生缺陷之一。腭的形成是一个复杂的过程，导致口腔和鼻腔的分离，涉及多个事件，包括腭的生长、提升和融合。最近的研究结果表明，转化生长因子-β（TGF-β）信号在腭上皮和间质中调节腭发育中起着至关重要的作用。在这里，我们强调了我们对TGF-β信号在腭发育过程中的理解的最新进展。
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