Whittaker Danielle E, English Kate, McGonnell Imelda M, Volk Holger A
Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL97TA, UK.
J Vet Diagn Invest. 2011 Mar;23(2):302-7. doi: 10.1177/104063871102300216.
Syringomyelia is a common clinical problem in the Cavalier King Charles Spaniel dog population. The underlying pathophysiology of the development and progression of syringes is currently unknown. The primary aim of the current study was to determine whether development of syringomyelia is accompanied by alterations in cerebrospinal fluid composition. Patient records of Cavalier King Charles Spaniels with Chiari-like malformations, with or without concurrent syringomyelia, that had magnetic resonance imaging and cerebrospinal fluid analysis between December 2004 and December 2009, were retrospectively reviewed. Total nucleated cell count per microliter, with differential count, red blood cell count per microliter, and protein concentration (g/l), were reviewed. Data were analyzed with the Mann-Whitney U-test. Spearman rank test was used to test association between cerebrospinal fluid composition and syrinx size, and the Fisher exact test was used to compare the presence of macrophages, reactive lymphocytes, and myelin. A P value of ≤ 0.05 was considered significant for statistical tests. Dogs with syringomyelia had a higher total nucleated cell count (syringomyelia: 4/µl [range, 0-15/µl] vs. without syringomyelia: 2/µl [0-8/µl]; P = 0.0047), higher protein concentration (syringomyelia: 0.26 g/l [0.07-0.42 g/l] vs. without syringomyelia: 0.2 g/l [0.12-0.39 g/l]; P = 0.039), and an increased neutrophil percentage (syringomyelia: 0% [0-37%] vs. without syringomyelia: 0% [0-21%]; P = 0.0203) than those with the Chiari-like malformation alone. There was a positive correlation between total nucleated cell count and syrinx size (r = 0.51; P = 0.0068). Development of syringomyelia is accompanied by alterations in cerebrospinal fluid composition. The pathogenesis of syringomyelia has not been fully elucidated; therefore, the exact origin of cerebrospinal fluid changes remains unclear.
脊髓空洞症是英国王室查理士王小猎犬群体中常见的临床问题。目前尚不清楚脊髓空洞症发生和进展的潜在病理生理学机制。本研究的主要目的是确定脊髓空洞症的发生是否伴有脑脊液成分的改变。对2004年12月至2009年12月期间接受磁共振成像和脑脊液分析的患有Chiari样畸形（伴或不伴脊髓空洞症）的英国王室查理士王小猎犬的病历进行回顾性研究。回顾了每微升的总核细胞计数及分类计数、每微升的红细胞计数和蛋白质浓度（g/l）。数据采用Mann-Whitney U检验进行分析。Spearman秩和检验用于检验脑脊液成分与空洞大小之间的相关性，Fisher精确检验用于比较巨噬细胞、反应性淋巴细胞和髓磷脂的存在情况。统计学检验中，P值≤0.05被认为具有显著性。与单纯患有Chiari样畸形的犬相比，患有脊髓空洞症的犬总核细胞计数更高（脊髓空洞症：4/µl [范围，0 - 15/µl] 对比无脊髓空洞症：2/µl [0 - 8/µl]；P = 0.0047）、蛋白质浓度更高（脊髓空洞症：0.26 g/l [0.07 - 0.42 g/l] 对比无脊髓空洞症：0.2 g/l [0.12 - 0.39 g/l]；P = 0.039）以及中性粒细胞百分比增加（脊髓空洞症：0% [0 - 37%] 对比无脊髓空洞症：0% [0 - 21%]；P = 0.0203）。总核细胞计数与空洞大小之间存在正相关（r = 0.51；P = 0.0068）。脊髓空洞症的发生伴有脑脊液成分的改变。脊髓空洞症的发病机制尚未完全阐明；因此，脑脊液变化的确切起源仍不清楚。
