Cohen E A, Dehni G, Sodroski J G, Haseltine W A
Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts.
J Virol. 1990 Jun;64(6):3097-9. doi: 10.1128/JVI.64.6.3097-3099.1990.
The vpr product of the human immunodeficiency virus type 1 (HIV-1) acts in trans to accelerate virus replication and cytopathic effect in T cells. Here it is shown that the HIV-1 viral particle contains multiple copies of the vpr protein. The vpr product is the first regulatory protein of HIV-1 to be found in the virus particle. This observation raises the possibility that vpr acts to facilitate the early steps of infection before de novo viral protein synthesis occurs.
人类免疫缺陷病毒1型（HIV-1）的病毒蛋白R（Vpr）可反式作用，加速T细胞中的病毒复制及细胞病变效应。本文显示，HIV-1病毒颗粒含有多个Vpr蛋白拷贝。Vpr产物是在病毒颗粒中发现的首个HIV-1调节蛋白。这一观察结果提示，Vpr可能在病毒从头合成蛋白质之前促进感染的早期步骤。
