1型和2型人类免疫缺陷病毒的病毒蛋白R对于淋巴细胞中的复制和细胞致病性而言并非必需。
Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells.
作者信息
Dedera D, Hu W, Vander Heyden N, Ratner L
机构信息
Department of Medicine, Washington University, St. Louis, Missouri 63110.
出版信息
J Virol. 1989 Jul;63(7):3205-8. doi: 10.1128/JVI.63.7.3205-3208.1989.
Abstract
Viral protein R (VPR) is conserved in human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2). To assess its function, we have constructed mutations within the vpr coding regions of HIV-1 and HIV-2 predicted to express truncated VPR products. Infectious virus was produced by each proviral clone and showed similar replication kinetics and cytopathogenicity when compared with the corresponding parental proviral clone.
摘要
病毒蛋白R（VPR）在1型和2型人类免疫缺陷病毒（HIV-1和HIV-2）中是保守的。为了评估其功能，我们在HIV-1和HIV-2的vpr编码区域内构建了预测会表达截短VPR产物的突变。每个原病毒克隆都产生了有感染性的病毒，与相应的亲本原病毒克隆相比，其复制动力学和细胞致病性相似。
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