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1
Are probiotics safe for use during pregnancy and lactation?益生菌在妊娠和哺乳期使用安全吗?
Can Fam Physician. 2011 Mar;57(3):299-301.
2
Effect of maternal supplement beverage with and without probiotics during pregnancy and lactation on maternal and infant health: a randomized controlled trial in the Philippines.孕期和哺乳期补充含益生菌和不含益生菌的母体补充饮料对母婴健康的影响:菲律宾的一项随机对照试验。
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3
Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial.围产期女性服用多菌株益生菌产品对母乳细胞因子谱有不同影响,且可能对新生儿胃肠道功能症状有有益作用。一项随机临床试验。
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Are Probiotics and Prebiotics Safe for Use during Pregnancy and Lactation? A Systematic Review and Meta-Analysis.益生菌和益生元在妊娠和哺乳期使用安全吗?系统评价和荟萃分析。
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Probiotics for the treatment of bacterial vaginosis.用于治疗细菌性阴道病的益生菌。
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Probiotics: facts and myths.益生菌:事实与误解
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ILSI Europe perspective review: site-specific microbiota changes during pregnancy associated with biological consequences and clinical outcomes: opportunities for probiotic interventions.国际生命科学学会欧洲分会视角综述:孕期特定部位微生物群变化与生物学后果及临床结局的关联:益生菌干预的机遇
Gut Microbes. 2025 Dec;17(1):2501186. doi: 10.1080/19490976.2025.2501186. Epub 2025 May 21.
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Expert Opinion on the Use of Probiotics in Recurrent Pregnancy Loss.益生菌在复发性流产中的应用专家意见
Cureus. 2025 Mar 23;17(3):e81056. doi: 10.7759/cureus.81056. eCollection 2025 Mar.
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The Safety of Probiotics Intended for Use in Pregnant and Lactating Women: From a Desirable to a Required Task.用于孕妇和哺乳期妇女的益生菌安全性:从一项理想任务变为一项必要任务。
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Microbiota-targeted interventions and clinical implications for maternal-offspring health: An umbrella review of systematic reviews and meta-analyses of randomised controlled trials.靶向微生物组的干预措施及其对母婴健康的临床意义:系统评价和随机对照试验荟萃分析的伞状评价。
J Glob Health. 2024 Sep 13;14:04177. doi: 10.7189/jogh.14.04177.
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Effect of probiotic administration to breastfeeding mothers with very low birthweight neonates on some neonatal and maternal outcomes: study protocol for a randomised, double-blind, placebo-controlled trial.母乳喂养极低出生体重儿的母亲给予益生菌对一些新生儿和产妇结局的影响:一项随机、双盲、安慰剂对照试验的研究方案。
BMJ Open. 2024 Aug 29;14(8):e079526. doi: 10.1136/bmjopen-2023-079526.
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Targeting maternal gut microbiome to improve mental health outcomes-a pilot feasibility trial.针对孕妇肠道微生物群以改善心理健康结局——一项初步可行性试验
Front Psychiatry. 2024 Aug 7;15:1414291. doi: 10.3389/fpsyt.2024.1414291. eCollection 2024.
9
Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonisation (OPSiP trial): study protocol for a double-blind parallel group randomised placebo trial.孕期口服益生菌补充剂以减少B族链球菌定植(OPSiP试验):一项双盲平行组随机安慰剂试验的研究方案
BMJ Open. 2024 Feb 5;14(2):e076455. doi: 10.1136/bmjopen-2023-076455.
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The effects of synbiotic supplementation on blood pressure and other maternal outcomes in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial.益生菌联合补充剂对轻度子痫前期孕妇血压和其他母婴结局的影响:一项三盲随机对照试验。
BMC Womens Health. 2024 Jan 31;24(1):80. doi: 10.1186/s12905-024-02922-6.

本文引用的文献

1
Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study.母亲补充益生菌的饮食咨询对妊娠结局以及产前和产后生长的影响:一项双盲、安慰剂对照研究。
Br J Nutr. 2010 Jun;103(12):1792-9. doi: 10.1017/S0007114509993898. Epub 2010 Feb 4.
2
Dietary supplementation with lactobacilli and bifidobacteria is well tolerated and not associated with adverse events during late pregnancy and early infancy.在妊娠晚期和婴儿早期,补充乳酸杆菌和双歧杆菌的耐受性良好,与不良事件无关。
J Nutr. 2010 Mar;140(3):483-8. doi: 10.3945/jn.109.117093. Epub 2010 Jan 20.
3
Probiotic safety in pregnancy: a systematic review and meta-analysis of randomized controlled trials of Lactobacillus, Bifidobacterium, and Saccharomyces spp.
J Obstet Gynaecol Can. 2009 Jun;31(6):542-552. doi: 10.1016/S1701-2163(16)34218-9.
4
Probiotic lactobacilli in breast milk and infant stool in relation to oral intake during the first year of life.母乳和婴儿粪便中的益生菌乳酸菌与生命第一年的口服摄入量的关系。
J Pediatr Gastroenterol Nutr. 2009 Sep;49(3):349-54. doi: 10.1097/MPG.0b013e31818f091b.
5
The effects of selected probiotic strains on the development of eczema (the PandA study).特定益生菌菌株对湿疹发展的影响(PandA 研究)。
Allergy. 2009 Sep;64(9):1349-58. doi: 10.1111/j.1398-9995.2009.02021.x. Epub 2009 Apr 9.
6
Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort.益生菌可预防剖宫产儿童至5岁时与IgE相关的过敏,但对整个队列儿童无效。
J Allergy Clin Immunol. 2009 Feb;123(2):335-41. doi: 10.1016/j.jaci.2008.11.019. Epub 2009 Jan 8.
7
Effects of Lactobacillus GG treatment during pregnancy on the development of fetal antigen-specific immune responses.孕期服用鼠李糖乳杆菌GG对胎儿抗原特异性免疫反应发育的影响。
Clin Exp Allergy. 2008 Dec;38(12):1882-90. doi: 10.1111/j.1365-2222.2008.03100.x. Epub 2008 Sep 24.
8
Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial.产后益生菌和益生元(合生元)治疗的长期安全性及其对感染率的影响:随机、双盲、安慰剂对照试验
Pediatrics. 2008 Jul;122(1):8-12. doi: 10.1542/peds.2007-1192.
9
Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study.孕期母亲特应性体质及补充益生菌对婴儿致敏作用的影响:一项双盲安慰剂对照研究。
Clin Exp Allergy. 2008 Aug;38(8):1342-8. doi: 10.1111/j.1365-2222.2008.03008.x. Epub 2008 May 8.
10
The safety of probiotics.益生菌的安全性。
Clin Infect Dis. 2008 Feb 1;46 Suppl 2:S104-11; discussion S144-51. doi: 10.1086/523331.

益生菌在妊娠和哺乳期使用安全吗?

Are probiotics safe for use during pregnancy and lactation?

出版信息

Can Fam Physician. 2011 Mar;57(3):299-301.

PMID:21402964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3056676/
Abstract

QUESTION

There has been a great deal of discussion in both the medical and lay literature about the use of probiotics to improve general health. Subsequently, pregnant women have been asking me if probiotics used for treating conditions such as bacterial vaginosis and diarrhea are safe to use during pregnancy and lactation.

ANSWER

Current data suggest that probiotic supplementation is rarely systemically absorbed when used by healthy individuals. One meta-analysis and several randomized controlled trials conducted with women during the third trimester of pregnancy did not report an increase in adverse fetal outcomes. There have been no published studies addressing Saccharomyces species use in pregnancy. Probiotics are unlikely to be transferred into breast milk.

摘要

问题

医学和大众文献中都有大量关于使用益生菌来改善整体健康的讨论。因此,孕妇们一直问我,用于治疗细菌性阴道病和腹泻等疾病的益生菌在怀孕期间和哺乳期使用是否安全。

答案

目前的数据表明,健康个体使用益生菌时,很少会被系统吸收。一项荟萃分析和几项在妊娠晚期进行的随机对照试验都没有报告胎儿不良结局增加。目前还没有关于妊娠期间使用酿酒酵母属的研究。益生菌不太可能转移到母乳中。