益生菌在妊娠和哺乳期使用安全吗？
Are probiotics safe for use during pregnancy and lactation?
出版信息
Can Fam Physician. 2011 Mar;57(3):299-301.
Abstract
QUESTION
There has been a great deal of discussion in both the medical and lay literature about the use of probiotics to improve general health. Subsequently, pregnant women have been asking me if probiotics used for treating conditions such as bacterial vaginosis and diarrhea are safe to use during pregnancy and lactation.
ANSWER
Current data suggest that probiotic supplementation is rarely systemically absorbed when used by healthy individuals. One meta-analysis and several randomized controlled trials conducted with women during the third trimester of pregnancy did not report an increase in adverse fetal outcomes. There have been no published studies addressing Saccharomyces species use in pregnancy. Probiotics are unlikely to be transferred into breast milk.
摘要
问题
医学和大众文献中都有大量关于使用益生菌来改善整体健康的讨论。因此，孕妇们一直问我，用于治疗细菌性阴道病和腹泻等疾病的益生菌在怀孕期间和哺乳期使用是否安全。
答案
目前的数据表明，健康个体使用益生菌时，很少会被系统吸收。一项荟萃分析和几项在妊娠晚期进行的随机对照试验都没有报告胎儿不良结局增加。目前还没有关于妊娠期间使用酿酒酵母属的研究。益生菌不太可能转移到母乳中。
相似文献
1
Are probiotics safe for use during pregnancy and lactation?
Can Fam Physician. 2011 Mar;57(3):299-301.
2
Effect of maternal supplement beverage with and without probiotics during pregnancy and lactation on maternal and infant health: a randomized controlled trial in the Philippines.
BMC Pregnancy Childbirth. 2018 May 31;18(1):193. doi: 10.1186/s12884-018-1828-8.
3
Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial.
Nutrients. 2016 Oct 27;8(11):677. doi: 10.3390/nu8110677.
4
Are Probiotics and Prebiotics Safe for Use during Pregnancy and Lactation? A Systematic Review and Meta-Analysis.
Nutrients. 2021 Jul 13;13(7):2382. doi: 10.3390/nu13072382.
5
Probiotics for the Treatment of Bacterial Vaginosis: A Meta-Analysis.
Int J Environ Res Public Health. 2019 Oct 12;16(20):3859. doi: 10.3390/ijerph16203859.
6
Comparative efficacy of probiotic yoghurt and clindamycin in treatment of bacterial vaginosis in pregnant women: a randomized clinical trial.
J Matern Fetal Neonatal Med. 2012 Jul;25(7):1021-4. doi: 10.3109/14767058.2011.614654. Epub 2011 Oct 1.
7
Probiotics for the prevention of pediatric antibiotic-associated diarrhea.
Cochrane Database Syst Rev. 2015 Dec 22(12):CD004827. doi: 10.1002/14651858.CD004827.pub4.
8
Probiotics for the treatment of bacterial vaginosis.
Cochrane Database Syst Rev. 2009 Oct 7(4):CD006289. doi: 10.1002/14651858.CD006289.pub2.
9
Probiotics: facts and myths.
Clin Microbiol Infect. 2005 Dec;11(12):958-66. doi: 10.1111/j.1469-0691.2005.01228.x.
10
Probiotics for the prevention of pediatric antibiotic-associated diarrhea.
Cochrane Database Syst Rev. 2011 Nov 9(11):CD004827. doi: 10.1002/14651858.CD004827.pub3.
引用本文的文献
1
in Peripartum Women: Review of Outcomes and Treatment.
Antibiotics (Basel). 2025 Aug 15;14(8):829. doi: 10.3390/antibiotics14080829.
2
ILSI Europe perspective review: site-specific microbiota changes during pregnancy associated with biological consequences and clinical outcomes: opportunities for probiotic interventions.
Gut Microbes. 2025 Dec;17(1):2501186. doi: 10.1080/19490976.2025.2501186. Epub 2025 May 21.
3
Expert Opinion on the Use of Probiotics in Recurrent Pregnancy Loss.
Cureus. 2025 Mar 23;17(3):e81056. doi: 10.7759/cureus.81056. eCollection 2025 Mar.
4
The Safety of Probiotics Intended for Use in Pregnant and Lactating Women: From a Desirable to a Required Task.
Foods. 2024 Dec 12;13(24):4024. doi: 10.3390/foods13244024.
5
Nutraceuticals in Pregnancy: A Special Focus on Probiotics.
Int J Mol Sci. 2024 Sep 7;25(17):9688. doi: 10.3390/ijms25179688.
6
Microbiota-targeted interventions and clinical implications for maternal-offspring health: An umbrella review of systematic reviews and meta-analyses of randomised controlled trials.
J Glob Health. 2024 Sep 13;14:04177. doi: 10.7189/jogh.14.04177.
7
Effect of probiotic administration to breastfeeding mothers with very low birthweight neonates on some neonatal and maternal outcomes: study protocol for a randomised, double-blind, placebo-controlled trial.
BMJ Open. 2024 Aug 29;14(8):e079526. doi: 10.1136/bmjopen-2023-079526.
8
Targeting maternal gut microbiome to improve mental health outcomes-a pilot feasibility trial.
Front Psychiatry. 2024 Aug 7;15:1414291. doi: 10.3389/fpsyt.2024.1414291. eCollection 2024.
9
Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonisation (OPSiP trial): study protocol for a double-blind parallel group randomised placebo trial.
BMJ Open. 2024 Feb 5;14(2):e076455. doi: 10.1136/bmjopen-2023-076455.
10
The effects of synbiotic supplementation on blood pressure and other maternal outcomes in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial.
BMC Womens Health. 2024 Jan 31;24(1):80. doi: 10.1186/s12905-024-02922-6.
本文引用的文献
1
Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study.
Br J Nutr. 2010 Jun;103(12):1792-9. doi: 10.1017/S0007114509993898. Epub 2010 Feb 4.
2
Dietary supplementation with lactobacilli and bifidobacteria is well tolerated and not associated with adverse events during late pregnancy and early infancy.
J Nutr. 2010 Mar;140(3):483-8. doi: 10.3945/jn.109.117093. Epub 2010 Jan 20.
3
Probiotic safety in pregnancy: a systematic review and meta-analysis of randomized controlled trials of Lactobacillus, Bifidobacterium, and Saccharomyces spp.
J Obstet Gynaecol Can. 2009 Jun;31(6):542-552. doi: 10.1016/S1701-2163(16)34218-9.
4
Probiotic lactobacilli in breast milk and infant stool in relation to oral intake during the first year of life.
J Pediatr Gastroenterol Nutr. 2009 Sep;49(3):349-54. doi: 10.1097/MPG.0b013e31818f091b.
5
The effects of selected probiotic strains on the development of eczema (the PandA study).
Allergy. 2009 Sep;64(9):1349-58. doi: 10.1111/j.1398-9995.2009.02021.x. Epub 2009 Apr 9.
6
Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort.
J Allergy Clin Immunol. 2009 Feb;123(2):335-41. doi: 10.1016/j.jaci.2008.11.019. Epub 2009 Jan 8.
7
Effects of Lactobacillus GG treatment during pregnancy on the development of fetal antigen-specific immune responses.
Clin Exp Allergy. 2008 Dec;38(12):1882-90. doi: 10.1111/j.1365-2222.2008.03100.x. Epub 2008 Sep 24.
8
Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial.
Pediatrics. 2008 Jul;122(1):8-12. doi: 10.1542/peds.2007-1192.
9
Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study.
Clin Exp Allergy. 2008 Aug;38(8):1342-8. doi: 10.1111/j.1365-2222.2008.03008.x. Epub 2008 May 8.
10
The safety of probiotics.
Clin Infect Dis. 2008 Feb 1;46 Suppl 2:S104-11; discussion S144-51. doi: 10.1086/523331.
Zotero 插件