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Angiotensin-(1-7) inhibits sodium transport via Mas receptor by increasing nitric oxide production in thick ascending limb.血管紧张素 -（1 - 7）通过增加髓袢升支粗段一氧化氮的生成，经Mas受体抑制钠转运。
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Fructose acutely stimulates NKCC2 activity in rat thick ascending limbs by increasing surface NKCC2 expression.果糖通过增加 NKCC2 表面表达，使大鼠升支粗段 NKCC2 活性急性增加。
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本文引用的文献

1
Regulation of renal NaCl transport by nitric oxide, endothelin, and ATP: clinical implications.一氧化氮、内皮素和 ATP 对肾脏 NaCl 转运的调节：临床意义。
Annu Rev Physiol. 2011;73:359-76. doi: 10.1146/annurev-physiol-012110-142247.
2
Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.WNK1 肾脏特异性同工型失活后， ENaC 表达减少补偿了 NCC 活性的增加，防止了高血压的发生。
Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18109-14. doi: 10.1073/pnas.1006128107. Epub 2010 Oct 4.
3
Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene.全基因组荟萃分析血清钙确定了钙敏感受体（CASR）基因附近具有显著相关性的单核苷酸多态性（SNP）。
PLoS Genet. 2010 Jul 22;6(7):e1001035. doi: 10.1371/journal.pgen.1001035.
4
Race, sex, and the regulation of urine osmolality: observations made during water deprivation.种族、性别与尿渗透压调节：禁水期观察。
Am J Physiol Regul Integr Comp Physiol. 2010 Sep;299(3):R977-80. doi: 10.1152/ajpregu.00289.2010. Epub 2010 Jun 23.
5
US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008.美国高血压的患病率、知晓率、治疗率和控制率趋势，1988-2008 年。
JAMA. 2010 May 26;303(20):2043-50. doi: 10.1001/jama.2010.650.
6
Angiotensin II stimulates thick ascending limb NO production via AT(2) receptors and Akt1-dependent nitric-oxide synthase 3 (NOS3) activation.血管紧张素 II 通过 AT(2) 受体和 Akt1 依赖性一氧化氮合酶 3 (NOS3) 激活刺激厚升支的 NO 产生。
J Biol Chem. 2010 May 14;285(20):14932-14940. doi: 10.1074/jbc.M110.109041. Epub 2010 Mar 18.
7
Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure.连接细胞外液体积和血压的近端肾小管钠转运调节机制。
Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R851-61. doi: 10.1152/ajpregu.00002.2010. Epub 2010 Jan 27.
8
Racial differences in potassium homeostasis in response to differences in dietary sodium in girls.女孩对膳食钠差异的钾稳态的种族差异。
Am J Clin Nutr. 2010 Mar;91(3):597-603. doi: 10.3945/ajcn.2009.28400. Epub 2009 Dec 9.
9
Common genetic variation and human traits.常见基因变异与人类性状
N Engl J Med. 2009 Apr 23;360(17):1696-8. doi: 10.1056/NEJMp0806284. Epub 2009 Apr 15.
10
Ethnic differences in proximal and distal tubular sodium reabsorption are heritable in black and white populations.近端和远端肾小管钠重吸收的种族差异在黑人和白人人群中具有遗传性。
J Hypertens. 2009 Mar;27(3):606-12. doi: 10.1097/HJH.0b013e32832104b1.

Sodium reabsorption in the thick ascending limb in relation to blood pressure: a clinical perspective.

作者信息

Jung Jeesun, Basile David P, Pratt J Howard

机构信息

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.

出版信息

Hypertension. 2011 May;57(5):873-9. doi: 10.1161/HYPERTENSIONAHA.108.120246. Epub 2011 Mar 14.

DOI:10.1161/HYPERTENSIONAHA.108.120246
PMID:21403087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3132653/
Abstract
摘要