Dipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo, Via Saffi 2, Urbino, Italy.
Amino Acids. 2011 May;40(5):1385-96. doi: 10.1007/s00726-011-0875-5. Epub 2011 Mar 15.
Creatine monohydrate (Cr), the most diffuse supplement in the sports industry, is receiving greater attention because of its beneficial effects in a wide number of human degenerative diseases and conditions. These effects can be barely explained on the basis of the sole ergogenic role of the Cr/CrP system. Indeed, a wide number of research articles indicate that Cr is capable of exerting multiple, non-energy related, effects on diverse and relevant cellular targets. Among these effects, the antioxidant activity of Cr emerges as an additional mechanism which is likely to play a supportive role in the Cr-cytoprotection paradigm.
一水肌酸（Cr）是运动行业中最常见的补充剂，由于其在多种人类退行性疾病和病症中的有益作用，受到了更多关注。这些作用仅用 Cr/CrP 系统的唯一的运动表现增强作用是很难解释的。事实上，大量研究文章表明 Cr 能够对多种相关的细胞靶标发挥多种非能量相关的作用。在这些作用中，Cr 的抗氧化活性是一种额外的机制，可能在 Cr 细胞保护范式中发挥支持作用。
