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脂质颗粒的体内异常扩散和弱遍历破坏。

In vivo anomalous diffusion and weak ergodicity breaking of lipid granules.

机构信息

Physics Department T30g, Technical University of Munich, Garching, Germany.

出版信息

Phys Rev Lett. 2011 Jan 28;106(4):048103. doi: 10.1103/PhysRevLett.106.048103. Epub 2011 Jan 25.

DOI:10.1103/PhysRevLett.106.048103
PMID:21405366
Abstract

Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking. Namely we demonstrate that at short times the granules perform subdiffusion according to the laws of continuous time random walk theory. The associated violation of ergodicity leads to a characteristic turnover between two scaling regimes of the time averaged mean squared displacement. At longer times the granule motion is consistent with fractional Brownian motion.

摘要

我们将活裂殖酵母细胞内源性脂质颗粒的广泛单颗粒跟踪显微镜数据与分析结果相结合,证明了反常扩散和弱遍历破坏的证据。具体来说,我们证明了在短时间内,颗粒根据连续时间随机行走理论表现出亚扩散。这种遍历性的破坏导致了时间平均均方位移的两个标度律之间的特征转换。在更长的时间内,颗粒的运动与分数布朗运动一致。

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