Vanderwolf C H, Dickson C T, Baker G B
Department of Psychology, University of Western Ontario, London, Canada.
Pharmacol Biochem Behav. 1990 Apr;35(4):847-53. doi: 10.1016/0091-3057(90)90369-s.
Rats were trained on a conventional maze test or on a swim-to-platform test. Retention of swim-to-platform performance 7 days later was severely impaired by posttraining treatment with a combination of p-chlorophenylalanine (PCPA) and scopolamine although neither drug alone had any effect. Retention of the maze habit was moderately impaired by scopolamine alone and severely impaired by a combination of scopolamine and PCPA, but was unaffected by PCPA alone. Polygraphic recordings confirmed previous reports that a combination of PCPA and scopolamine can abolish neocortical low voltage fast activity and hippocampal rhythmical slow activity. Combined blockade of central cholinergic and serotonergic neurotransmission in rats may provide a useful animal model of Alzheimer's disease.
将大鼠置于传统迷宫测试或游泳至平台测试中进行训练。7天后，用对氯苯丙氨酸（PCPA）和东莨菪碱联合进行训练后处理，严重损害了游泳至平台测试的表现，尽管单独使用任何一种药物均无任何影响。单独使用东莨菪碱中度损害了迷宫习惯的保持，而东莨菪碱和PCPA联合使用则严重损害了迷宫习惯的保持，但单独使用PCPA则没有影响。多导记录证实了先前的报道，即PCPA和东莨菪碱联合使用可消除新皮质低电压快速活动和海马节律性慢活动。大鼠中枢胆碱能和5-羟色胺能神经传递的联合阻断可能为阿尔茨海默病提供一种有用的动物模型。
