Department of Blood Bank & Haemostasis, National Institute of Blood Disease & Bone Marrow Transplantation.
Clin Appl Thromb Hemost. 2011 Nov-Dec;17(6):651-5. doi: 10.1177/1076029611398122. Epub 2011 Mar 14.
The aim of the study was to assess the prevalence of HCV, HBV, and HIV infections among the patients with hemophilia. Patients with Hemophilia A and B were evaluated who visited hospital for factor replacement therapy. The viral markers tested in these patients included anti-HCV-Ab, HBsAg, and anti-HIV-Ab. Seroprevalence was compared from 5717 exchange healthy blood donors for same markers. A total of 173 multitransfused male hemophiliacs showed prevalence of 51.4% for HCV, 1.73% for HBV, and nil for HIV. In blood donors seroprevalence was 1.9% for HCV, 1.81% for HBV, while no HIV-positive case was detected. Prevalence of anti-HCV-Ab was significantly high in patients with hemophilia than normal donors (P = .0005). This study showed that HCV infection was more frequently identified than HBV and HIV infections in multitransfused hemophiliacs. The frequency of hepatitis C among blood donors is also higher than that of hepatitis B which is showing downward trend.
本研究旨在评估血友病患者中丙型肝炎病毒（HCV）、乙型肝炎病毒（HBV）和人类免疫缺陷病毒（HIV）感染的流行情况。评估了前来医院接受因子替代疗法的甲型和乙型血友病患者。这些患者检测的病毒标志物包括抗 HCV-Ab、HBsAg 和抗 HIV-Ab。对相同标志物的 5717 名交换健康献血者进行了血清流行率比较。173 名多次输血的男性血友病患者中，HCV 的流行率为 51.4%，HBV 为 1.73%，HIV 为零。献血者的 HCV 血清流行率为 1.9%，HBV 为 1.81%，未检测到 HIV 阳性病例。与正常供体相比，血友病患者抗 HCV-Ab 的流行率显著升高（P=0.0005）。本研究表明，在多次输血的血友病患者中，HCV 感染比 HBV 和 HIV 感染更为常见。献血者中丙型肝炎的频率也高于乙型肝炎，乙型肝炎呈下降趋势。
