Department of the Biochemistry, Faculty of medicine, Kateb University, Kabul, Afghanistan.
Afghanistan National Charity organization for Special Diseases (ANCOSD), Kabul, Afghanistan.
Sci Rep. 2019 May 13;9(1):7259. doi: 10.1038/s41598-019-43541-8.
Blood-borne viruses including Hepatitis B and C, HIV, HTLV-1 and parvovirus B19 are still a factor of concern, especially for hemophilia patients. Although the safety of the blood supply continues to improve worldwide, the blood supply system in Afghanistan was damaged by many years of conflict and political instability. To date, there are few studies focused on the prevalence of blood-borne viruses in hemophilia patients. This study is first to investigate the prevalence of five blood-borne viruses in Afghanistan hemophilia patients in four cities including Kabul, Herat, Mazar-i-Sharif and Jalal Abad. A total of 80 hemophilia male patients were screening for the presence of five transfusion-transmitted viruses using ELISA and PCR. Data obtained showed 2.5% seropositivity for HBV, 8.75% seropositivity for HCV, and 91.25% seropositivity for parvovirus B19. None of the patients were positive for HIV and HTLV-1 and the prevalence of HCV was higher in older patients rather than younger patients. This finding, the first to report in Afghanistan, shows a high prevalence of parvovirus B19 in Afghanistan hemophilia patients and implementation of highly sensitive screening is necessary.
血源病毒，包括乙型肝炎和丙型肝炎、艾滋病毒、人类嗜 T 淋巴细胞病毒 1 型和细小病毒 B19，仍然是一个令人关注的因素，尤其是对血友病患者而言。尽管全球范围内血液供应的安全性不断提高，但阿富汗的血液供应系统在多年的冲突和政治不稳定中受到了破坏。迄今为止，很少有研究关注血友病患者中血源病毒的流行情况。本研究首次调查了阿富汗四个城市（喀布尔、赫拉特、马扎里沙里夫和贾拉拉巴德）的血友病男性患者中五种血源病毒的流行情况。共对 80 名血友病男性患者进行了酶联免疫吸附试验和聚合酶链反应检测，以筛查五种输血传播病毒的存在情况。获得的数据显示，HBV 的血清阳性率为 2.5%，HCV 的血清阳性率为 8.75%，细小病毒 B19 的血清阳性率为 91.25%。未发现 HIV 和 HTLV-1 阳性患者，且 HCV 的患病率在老年患者中高于年轻患者。这一发现是阿富汗首例报告，表明阿富汗血友病患者中细小病毒 B19 的流行率很高，有必要实施高度敏感的筛查。
