Gannagé-Yared Marie-Hélène, Chedid Rima, Halaby Georges
Division of Endocrinology, Hôtel-Dieu de France Hospital, St Joseph University (USJ), Beirut, Lebanon.
J Med Liban. 2010 Oct-Dec;58(4):191-4.
Vitamin D inadequacy is highly prevalent in Lebanon in young adults, school children and postmenopausal osteoporotic women. However, this prevalence has not been previously studied in university students. Three hundred and eighty-one students (mean age 23.9 +/- 3.9 years), randomly recruited from Saint-Joseph University, were included in this cross-sectional study (201 males and 180 females). Recruitment was performed across all seasons. The mean 25 hydroxyvitamin D (25(OH)D) was 31 +/- 12A ng/ml. 25(OH)D was inversely correlated with BMI and waist circumference (r = -0.18 and r = -0.19,p < 0.001 for both variables). 25(OH)D was significantly different between the winter season and the other seasons (p = 0.023, p = 0.001 and p < 0.0001 for spring, summer and fall respectively). 25(OH)D was lower in men compared to women (29.01 +/- 11.23 versus 33.2 +/- 13A, p < 0.01). This gender difference disappears after adjustment for both season and BMI. In addition, the inverse relation between 25(OH)D and BMI was non significant in the female population. In a stepwise multilinear regression analysis using 25(OH)D as a dependent variable, season and BMI were the independent predictors of vitamin D levels (p < 0.0001 and p = 0.001 respectively). Our results suggest that, in a population of high educational level, vitamin D status is better compared to other subgroups of the Lebanese population. In addition, we found, after adjustment for BMI and season, no gender difference in 25(OH)D levels while the winter season and a high BMI negatively affect vitamin D status.
维生素D不足在黎巴嫩的年轻人、学童和绝经后骨质疏松妇女中非常普遍。然而，此前尚未对大学生中的这种患病率进行过研究。本横断面研究纳入了从圣约瑟夫大学随机招募的381名学生（平均年龄23.9±3.9岁）（201名男性和180名女性）。招募在所有季节进行。25羟维生素D（25(OH)D）的平均水平为31±12纳克/毫升。25(OH)D与体重指数（BMI）和腰围呈负相关（r = -0.18和r = -0.19，两个变量的p均<0.001）。冬季与其他季节的25(OH)D水平存在显著差异（春季、夏季和秋季的p分别为0.023、0.001和<0.0001）。男性的25(OH)D水平低于女性（29.01±11.23对33.2±13，p<0.01）。在对季节和BMI进行调整后，这种性别差异消失。此外，25(OH)D与BMI之间的负相关在女性人群中不显著。在以25(OH)D为因变量的逐步多元线性回归分析中，季节和BMI是维生素D水平的独立预测因素（p分别<0.0001和p = 0.001）。我们的结果表明，在高教育水平人群中，维生素D状况优于黎巴嫩人群的其他亚组。此外，在对BMI和季节进行调整后，我们发现25(OH)D水平不存在性别差异，而冬季和高BMI会对维生素D状况产生负面影响。
