Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia 26506-9190, USA.
J Clin Endocrinol Metab. 2011 Jun;96(6):1747-53. doi: 10.1210/jc.2010-2401. Epub 2011 Mar 16.
Perfluorocarbons (PFC) are man-made chemicals used in numerous household products. They have a long half-life in humans and complex animal toxicity, and accumulating evidence points toward associations with multiple human health endpoints.
Our objective was to investigate whether PFC are associated with endocrine disruption in women.
Cross-sectional analyses were made between quintiles of serum PFC, serum estradiol, and menopause onset.
The C8 Health Project, with cohort of 69,030 adults and children, was conducted due to PFC contamination of drinking water from six water districts in two states.
Participants included 25,957 women aged 18-65 yr.
Serum estradiol levels and onset of menopause were assessed. The survey was the result of a class action suit, and survey designers (an independent corporation) had no a priori hypotheses. All hypotheses have been formulated by other investigators after data collection.
After excluding women who reported hysterectomy and adjusting for age within the group, smoking, alcohol consumption, body mass index, and exercise, the odds of having experienced menopause were significantly higher in the highest quintile relative to the lowest quintile of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) in the perimenopausal [PFOS odds = 1.4, confidence interval (CI) = 1.1-1.8; PFOA odds =1.4, CI = 1.1-1.8] and menopausal age groups (PFOS odds = 2.1, CI=1.6-2.8; PFOA odds = 1.7, CI = 1.3-2.3). After appropriate exclusions and adjustment for covariates, there was a significant inverse association between PFOS and estradiol in perimenopausal (β = -3.65; P < 0.0001) and menopausal age groups (β = -0.83; P = 0.007) but not between PFOA and estradiol.
These data suggest that PFC are associated with endocrine disruption in women and that further research on mechanisms is warranted.
全氟化合物（PFC）是在众多家用产品中使用的人造化学品。它们在人体内的半衰期长，且具有复杂的动物毒性，越来越多的证据表明它们与多种人类健康终点有关。
我们的目的是研究 PFC 是否与女性内分泌紊乱有关。
在血清 PFC、雌二醇和绝经发作的五分位数之间进行了横断面分析。
C8 健康项目，是在两个州的六个水区饮用水受到 PFC 污染的情况下，对 69030 名成人和儿童进行的一项队列研究。
参与者包括 25957 名年龄在 18-65 岁的女性。
评估血清雌二醇水平和绝经发作情况。该调查是一项集体诉讼的结果，调查设计者（一家独立公司）没有先验假设。所有假设都是在数据收集后由其他研究人员提出的。
在排除了报告有子宫切除术的女性，并在组内按年龄进行调整后，在围绝经期和绝经年龄组中，与最低五分位数相比，最高五分位数的妇女发生绝经的几率显著更高，与全氟辛烷磺酸（PFOS）和全氟辛烷磺酸（PFOS）相关（PFOS 比值比 = 1.4，95%置信区间（CI）= 1.1-1.8；PFOA 比值比 = 1.4，CI = 1.1-1.8）和绝经年龄组（PFOS 比值比 = 2.1，CI=1.6-2.8；PFOA 比值比 = 1.7，CI = 1.3-2.3）。在适当的排除和协变量调整后，PFOS 与围绝经期（β=-3.65；P<0.0001）和绝经年龄组（β=-0.83；P=0.007）中雌二醇之间存在显著的负相关，但 PFOA 与雌二醇之间无相关性。
这些数据表明 PFC 与女性内分泌紊乱有关，需要进一步研究其机制。
