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Activity of andrographolide and its derivatives against influenza virus in vivo and in vitro.穿心莲内酯及其衍生物抗流感病毒的体内外活性。
Biol Pharm Bull. 2009 Aug;32(8):1385-91. doi: 10.1248/bpb.32.1385.
2
Use of tissue-engineered skin to study in vitro biofilm development.利用组织工程皮肤研究体外生物膜的形成。
Dermatol Surg. 2009 Sep;35(9):1334-41. doi: 10.1111/j.1524-4725.2009.01238.x. Epub 2009 May 12.
3
Signals, regulatory networks, and materials that build and break bacterial biofilms.构建和破坏细菌生物膜的信号、调控网络及物质。
Microbiol Mol Biol Rev. 2009 Jun;73(2):310-47. doi: 10.1128/MMBR.00041-08.
4
Synthesis and evaluation of antibacterial activities of andrographolide analogues.穿心莲内酯类似物的合成及其抗菌活性评价
Eur J Med Chem. 2009 Jul;44(7):2936-43. doi: 10.1016/j.ejmech.2008.12.014. Epub 2008 Dec 25.
5
Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa.抗生素对铜绿假单胞菌群体感应的影响。
Antimicrob Agents Chemother. 2008 Oct;52(10):3648-63. doi: 10.1128/AAC.01230-07. Epub 2008 Jul 21.
6
Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms.IV型菌毛、鞭毛介导的运动性及细胞外DNA在铜绿假单胞菌生物膜成熟多细胞结构形成中的作用
Environ Microbiol. 2008 Sep;10(9):2331-43. doi: 10.1111/j.1462-2920.2008.01658.x. Epub 2008 May 15.
7
Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms.针对铜绿假单胞菌生物膜的奥罗因文库的合成与筛选。
Chembiochem. 2008 May 23;9(8):1267-79. doi: 10.1002/cbic.200700774.
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Comparison of multiple methods for quantification of microbial biofilms grown in microtiter plates.微量滴定板中生长的微生物生物膜定量多种方法的比较
J Microbiol Methods. 2008 Feb;72(2):157-65. doi: 10.1016/j.mimet.2007.11.010. Epub 2007 Nov 21.
9
Quorum-sensing regulation of the biofilm matrix genes (pel) of Pseudomonas aeruginosa.铜绿假单胞菌生物膜基质基因（pel）的群体感应调控
J Bacteriol. 2007 Jul;189(14):5383-6. doi: 10.1128/JB.00137-07. Epub 2007 May 11.
10
High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections.高通量协同筛选确定微生物代谢产物为治疗真菌感染的联合用药。
Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4606-11. doi: 10.1073/pnas.0609370104. Epub 2007 Mar 5.

14-α-硫辛酸穿心莲内酯与多种抗生素对铜绿假单胞菌生物膜形成及胞外多糖和绿脓菌素产生的协同作用。

Synergistic effect of 14-alpha-lipoyl andrographolide and various antibiotics on the formation of biofilms and production of exopolysaccharide and pyocyanin by Pseudomonas aeruginosa.

机构信息

Institute of New Drug Research, Jinan University College of Pharmacy, Guangzhou 510632, China.

出版信息

Antimicrob Agents Chemother. 2011 Jun;55(6):3015-7. doi: 10.1128/AAC.00575-10. Epub 2011 Mar 21.

DOI:10.1128/AAC.00575-10
PMID:21422201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3101388/
Abstract

Pseudomonas aeruginosa produces a biofilm that provides the bacteria with an effective barrier against antibiotics. Here, we investigated the synergy of various antibiotics with 14-alpha-lipoyl andrographolide (AL-1), focusing upon synthesis of the biofilm. AL-1 also inhibited the production of the exopolysaccharide and pyocyanin components. We propose that AL-1 may potentially serve as a cotherapy to combat P. aeruginosa.

摘要

铜绿假单胞菌产生生物膜，为细菌提供了对抗生素的有效屏障。在这里，我们研究了各种抗生素与 14-α-硫辛酸穿心莲内酯（AL-1）的协同作用，重点是生物膜的合成。AL-1 还抑制了胞外多糖和绿脓菌素成分的产生。我们提出，AL-1 可能具有作为联合治疗来对抗铜绿假单胞菌的潜力。