Bonincontro Graziana, Scuderi Sarah Adriana, Marino Andreana, Simonetti Giovanna
Department of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro, 5, 00185 Roma, Italy.
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 98100 Messina, Italy.
Pharmaceuticals (Basel). 2023 Oct 30;16(11):1531. doi: 10.3390/ph16111531.
Bacterial and fungal biofilm has increased antibiotic resistance and plays an essential role in many persistent diseases. Biofilm-associated chronic infections are difficult to treat and reduce the efficacy of medical devices. This global problem has prompted extensive research to find alternative strategies to fight microbial chronic infections. Plant bioactive metabolites with antibiofilm activity are known to be potential resources to alleviate this problem. The phytochemical screening of some medicinal plants showed different active groups, such as stilbenes, tannins, alkaloids, terpenes, polyphenolics, flavonoids, lignans, quinones, and coumarins. Synergistic effects can be observed in the interaction between plant compounds and conventional drugs. This review analyses and summarises the current knowledge on the synergistic effects of plant metabolites in combination with conventional antimicrobials against biofilms of , , and . The synergism of conventional antimicrobials with plant compounds can modify and inhibit the mechanisms of acquired resistance, reduce undesirable effects, and obtain an appropriate therapeutic effect at lower doses. A deeper knowledge of these combinations and of their possible antibiofilm targets is needed to develop next-generation novel antimicrobials and/or improve current antimicrobials to fight drug-resistant infections attributed to biofilm.
细菌和真菌生物膜具有增强的抗生素耐药性，并且在许多持续性疾病中发挥着重要作用。与生物膜相关的慢性感染难以治疗，还会降低医疗器械的功效。这一全球性问题促使人们进行广泛研究，以寻找对抗微生物慢性感染的替代策略。已知具有抗生物膜活性的植物生物活性代谢产物是缓解这一问题的潜在资源。对一些药用植物的植物化学筛选显示出不同的活性基团，如芪类、单宁、生物碱、萜类、多酚类、黄酮类、木脂素、醌类和香豆素类。在植物化合物与传统药物的相互作用中可以观察到协同效应。本综述分析并总结了目前关于植物代谢产物与传统抗菌药物联合使用对金黄色葡萄球菌、铜绿假单胞菌和白色念珠菌生物膜协同效应的知识。传统抗菌药物与植物化合物的协同作用可以改变和抑制获得性耐药机制，减少不良影响，并在较低剂量下获得适当的治疗效果。为了开发下一代新型抗菌药物和/或改进现有抗菌药物以对抗由生物膜引起的耐药感染，需要更深入地了解这些组合及其可能的抗生物膜靶点。
