Arregui A, Iversen L L
Eur J Pharmacol. 1978 Nov 1;52(1):147-50. doi: 10.1016/0014-2999(78)90035-3.
The activity of angiotensin-converting enzyme in rat choroid plexus was higher than that of any other organ, being 6--7 times higher than that in lung and more than 50 times higher than in any other region of brain. Rabbit choroid plexus also had high activity of enzyme while that of human choroid plexus was relatively low. The enzyme in rat choroid plexus showed similar biochemical properties to that in other tissues; it was inhibited by the nonapeptide SQ 20,881, by (Sar1-Ala8)-angiotensin II and by EDTA, and required chloride ions for activity. As in other tissues, the choroid plexus enzyme was associated with particulate fractions after differential centrifugation. The corpus striatum and substantia nigra had the highest activities in the various brain regions examined.
大鼠脉络丛中血管紧张素转换酶的活性高于其他任何器官，比肺中的活性高6至7倍，比脑的其他任何区域高50多倍。兔脉络丛也具有较高的酶活性，而人脉络丛的酶活性相对较低。大鼠脉络丛中的酶与其他组织中的酶具有相似的生化特性；它被九肽SQ 20,881、(Sar1-Ala8)-血管紧张素II和EDTA抑制，并且活性需要氯离子。与其他组织一样，脉络丛酶在差速离心后与颗粒部分相关。在检查的各个脑区中，纹状体和黑质的活性最高。
