癫痫的饮食疗法：未来的研究。
Dietary therapies for epilepsy: future research.
机构信息
The John M. Freeman Pediatric Epilepsy Center, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
出版信息
Epilepsy Behav. 2011 Sep;22(1):17-22. doi: 10.1016/j.yebeh.2011.02.018. Epub 2011 Mar 26.
Abstract
Since 1921, dietary therapies have remained valuable options in the treatment of intractable childhood epilepsy. The traditional ketogenic diet has been well demonstrated, including in a recent randomized, controlled trial, as being highly effective. More recent alternative diets such as the medium-chain triglyceride diet, modified Atkins diet, and low-glycemic-index treatment have expanded the use of this modality to more children as well as adults. In this review, we discuss our top 10 most pressing research topics related to the ketogenic diet that warrant future study. As well, two promising ketogenic diet clinical researchers discuss their past and current research to help answer some of these questions.
摘要
自 1921 年以来，饮食疗法一直是治疗难治性儿童癫痫的有价值的选择。传统的生酮饮食已经得到了很好的证明，包括最近的一项随机对照试验，证明其非常有效。最近的其他替代饮食，如中链甘油三酯饮食、改良阿特金斯饮食和低血糖指数治疗，已经将这种治疗方法扩展到更多的儿童和成人。在这篇综述中，我们讨论了与生酮饮食相关的 10 个最紧迫的研究课题，这些课题值得进一步研究。此外，两位有前途的生酮饮食临床研究人员讨论了他们过去和现在的研究，以帮助回答其中的一些问题。
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本文引用的文献
1
The effect of the classical and medium chain triglyceride ketogenic diet on vitamin and mineral levels.经典型和中链甘油三酯生酮饮食对维生素和矿物质水平的影响。
J Hum Nutr Diet. 2012 Feb;25(1):16-26. doi: 10.1111/j.1365-277X.2011.01172.x. Epub 2011 May 27.
2
Early EEG improvement after ketogenic diet initiation.生酮饮食起始后早期脑电图改善。
Epilepsy Res. 2011 Mar;94(1-2):94-101. doi: 10.1016/j.eplepsyres.2011.01.012. Epub 2011 Feb 23.
3
Prospective study of the modified atkins diet in combination with a ketogenic liquid supplement during the initial month.在最初一个月期间，对改良阿特金斯饮食与生酮液体补充剂联合使用的前瞻性研究。
J Child Neurol. 2011 Feb;26(2):147-51. doi: 10.1177/0883073810375718. Epub 2010 Sep 10.
4
Long-term outcome and tolerability of the ketogenic diet in drug-resistant childhood epilepsy--the Austrian experience.抗药性儿童癫痫的生酮饮食长期疗效和耐受性——奥地利经验。
Seizure. 2010 Sep;19(7):404-8. doi: 10.1016/j.seizure.2010.06.006. Epub 2010 Jul 2.
5
Infantile spasms treated with the ketogenic diet: prospective single-center experience in 104 consecutive infants.酮饮食治疗婴儿痉挛：104 例连续婴儿前瞻性单中心经验。
Epilepsia. 2010 Aug;51(8):1403-7. doi: 10.1111/j.1528-1167.2010.02586.x. Epub 2010 Apr 30.
6
Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors.酮体可预防线粒体呼吸链复合物抑制剂诱导的突触功能障碍。
J Neurochem. 2010 Jul;114(1):130-41. doi: 10.1111/j.1471-4159.2010.06728.x. Epub 2010 Apr 2.
7
Long-term outcomes of children treated with the ketogenic diet in the past.过去接受生酮饮食治疗的儿童的长期结果。
Epilepsia. 2010 Jul;51(7):1277-82. doi: 10.1111/j.1528-1167.2009.02488.x. Epub 2010 Feb 1.
8
Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder.葡萄糖转运蛋白-1 缺乏综合征：一种可治疗疾病的临床表现和遗传谱不断扩大。
Brain. 2010 Mar;133(Pt 3):655-70. doi: 10.1093/brain/awp336. Epub 2010 Feb 2.
9
Effectiveness of the ketogenic diet in a broad range of seizure types and EEG features for severe childhood epilepsies.生酮饮食对儿童严重癫痫多种发作类型及脑电图特征的有效性。
Acta Neurol Scand. 2010 Jan;121(1):58-62. doi: 10.1111/j.1600-0404.2009.01303.x. Epub 2009 Nov 26.
10
Branched chain amino acids as adjunctive therapy to ketogenic diet in epilepsy: pilot study and hypothesis.支链氨基酸作为癫痫生酮饮食的辅助治疗：初步研究与假设
J Child Neurol. 2009 Oct;24(10):1268-72. doi: 10.1177/0883073809336295. Epub 2009 Aug 17.
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