The John M. Freeman Pediatric Epilepsy Center, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Epilepsy Behav. 2011 Sep;22(1):17-22. doi: 10.1016/j.yebeh.2011.02.018. Epub 2011 Mar 26.
Since 1921, dietary therapies have remained valuable options in the treatment of intractable childhood epilepsy. The traditional ketogenic diet has been well demonstrated, including in a recent randomized, controlled trial, as being highly effective. More recent alternative diets such as the medium-chain triglyceride diet, modified Atkins diet, and low-glycemic-index treatment have expanded the use of this modality to more children as well as adults. In this review, we discuss our top 10 most pressing research topics related to the ketogenic diet that warrant future study. As well, two promising ketogenic diet clinical researchers discuss their past and current research to help answer some of these questions.
自 1921 年以来，饮食疗法一直是治疗难治性儿童癫痫的有价值的选择。传统的生酮饮食已经得到了很好的证明，包括最近的一项随机对照试验，证明其非常有效。最近的其他替代饮食，如中链甘油三酯饮食、改良阿特金斯饮食和低血糖指数治疗，已经将这种治疗方法扩展到更多的儿童和成人。在这篇综述中，我们讨论了与生酮饮食相关的 10 个最紧迫的研究课题，这些课题值得进一步研究。此外，两位有前途的生酮饮食临床研究人员讨论了他们过去和现在的研究，以帮助回答其中的一些问题。
