Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cell Cycle. 2011 May 1;10(9):1363-9. doi: 10.4161/cc.10.9.15444.
The concept of a local bone marrow renin-angiotensin system (RAS) has been introduced and accumulating evidence suggests that the local RAS is actively involved in hematopoiesis. Angiotensin converting enzyme (ACE) is a key player in the RAS and makes the final effector angiotensin II. Besides angiotensin II, ACE also regulates a panel of bioactive peptides, such as substance P, Ac-SDKP and angiotensin 1-7. These peptides have also been individually reported in the regulation of pathways of hematopoiesis. In this setting, an ACE-regulated peptide network orchestrating hematopoiesis has emerged. Here, we focus on this peptide network and discuss the roles of ACE and its peptides in aspects of hematopoiesis. Special attention is given to the recent revelation that ACE is a bona fide marker of hematopoietic stem cells.
局部骨髓肾素-血管紧张素系统 (RAS) 的概念已经被提出，越来越多的证据表明局部 RAS 积极参与造血。血管紧张素转换酶 (ACE) 是 RAS 中的关键参与者，可生成最终效应物血管紧张素 II。除了血管紧张素 II 外，ACE 还调节一系列生物活性肽，如 P 物质、Ac-SDKP 和血管紧张素 1-7。这些肽也分别被报道参与了造血途径的调节。在这种情况下，一个由 ACE 调节的肽网络协调造血过程已经出现。在这里，我们专注于这个肽网络，并讨论 ACE 及其肽在造血方面的作用。特别关注最近的发现，即 ACE 是造血干细胞的真正标志物。
