Kitikoon Pravina, Sreta Donruethai, Na Ayudhya Suparlark Nuntawan, Wongphatcharachai Manoosak, Lapkuntod Jiradej, Prakairungnamthip Duangduean, Bunpapong Napawan, Suradhat Sanipa, Thanawongnuwech Roongroje, Amonsin Alongkorn
Emerging and Re-emerging Infectious Diseases in Animals, Research Unit, Faculty of Veterinary Science, Chulalongkorn University, Henri Dunant Rd., Bangkok, 10330, Thailand.
Virus Genes. 2011 Aug;43(1):1-5. doi: 10.1007/s11262-011-0597-5. Epub 2011 Mar 26.
For the past 10 years, endemic swine influenza H1 viruses in Thailand have been characterized as reassortants of swine virus genes from swine influenza viruses (SIV) in US and European pigs. Here the authors report the emergence of a novel reassorted H1N1 (rH1N1) virus consisted of human, avian, and swine virus genes from the pandemic H1N1 2009 (pH1N1) virus with a neuraminidase (NA) gene from a Thai swine H1N1 (ThH1N1) isolate. The rH1N1 virus was detected in nursery pigs during a respiratory disease outbreak in central Thailand in early 2010. The rH1N1 virus was repeatedly isolated from infected pigs, suggesting that it can transmit efficiently among the pig population. The appearance of rH1N1 virus in the field occurred within months of the introduction of pH1N1 virus into the Thai swine population in late 2009. The finding highlights the role of pig in generating newly reassorted influenza A viruses and also the significance of continuing disease surveillance and genetic characterization of SIV in pigs.
在过去10年里，泰国的地方性猪流感H1病毒一直被鉴定为源自美国和欧洲猪群中猪流感病毒（SIV）的猪病毒基因重配体。本文作者报告了一种新型重配H1N1（rH1N1）病毒的出现，该病毒由2009年大流行性H1N1（pH1N1）病毒的人、禽和猪病毒基因与一株泰国猪H1N1（ThH1N1）分离株的神经氨酸酶（NA）基因组成。2010年初在泰国中部一次呼吸道疾病暴发期间，在保育猪中检测到了rH1N1病毒。rH1N1病毒多次从感染猪中分离出来，表明它能在猪群中高效传播。rH1N1病毒在田间出现的时间是在2009年末pH1N1病毒引入泰国猪群后的几个月内。这一发现凸显了猪在产生新的重配甲型流感病毒中的作用，也凸显了持续开展猪流感疾病监测和猪SIV基因特征分析的重要性。
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