Sheu W H, Song Y M, Lee W J, Yao Y E, Lin C J, Tseng L N, Bau C T, Bai C L
Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taiwan, ROC.
Zhonghua Yi Xue Za Zhi (Taipei). 1999 Mar;62(3):146-51.
Type 2 diabetes mellitus (DM) is a well-known familial disease, although the genetics of this complex condition remains unclear. Recent evidence suggests the significance of maternal inheritance. However, the pattern of family aggregation and the influence of other family relatives on the mode of transmission in Chinese patients with diabetes are lacking.
We interviewed 449 patients (151 men and 298 women) with type 2 DM who were aged between 35 and 74 years with a mean age of 58 +/- 1 years in a referral hospital in central Taiwan. We recorded a detailed family history of diabetes for each patient.
Overall, 60% of diabetic patients had at least one diabetic family member. Among these index patients, 22.5% had a diabetic mother compared with 12.0% who had a diabetic father (p < 0.001). Approximately 29% of diabetic patients had at least one diabetic sister compared with 24% who had at least one diabetic brother (p = 0.13). A total of 27% of diabetic men had a diabetic mother, compared with 20% of diabetic women. Women with diabetes had more diabetic sisters than did diabetic men. In contrast, diabetic men had a significantly increased percentage of diabetic family members on the maternal side or paternal uncles or aunts than did diabetic women. The percentage of diabetic patients who had a diabetic mother decreased as their age increased. The maternal effect disappeared in the diabetic patients who were over 65 years old. Statistical differences between diabetic fathers and mothers were observed when DM was diagnosed in patients under 65 years of age.
We documented the presence of family aggregation and significant maternal inheritance in Chinese patients with type 2 DM in Taiwan. Further prospective study is needed to monitor the offspring of diabetic parents and other relatives in order to clarify the true mode of family aggregation and maternal transmission of type 2 DM.
2型糖尿病（DM）是一种众所周知的家族性疾病，尽管这种复杂病症的遗传学仍不清楚。最近的证据表明母系遗传的重要性。然而，在中国糖尿病患者中，家族聚集模式以及其他家族亲属对传播方式的影响尚缺乏相关研究。
我们在台湾中部一家转诊医院采访了449例年龄在35至74岁之间、平均年龄为58±1岁的2型糖尿病患者（151名男性和298名女性）。我们记录了每位患者详细的糖尿病家族史。
总体而言，60%的糖尿病患者至少有一名糖尿病家庭成员。在这些索引患者中，22.5%有糖尿病母亲，而有糖尿病父亲的比例为12.0%（p<0.001）。约29%的糖尿病患者至少有一个患糖尿病的姐妹，而至少有一个患糖尿病兄弟的比例为24%（p = 0.13）。共有27%的糖尿病男性有糖尿病母亲，而糖尿病女性这一比例为20%。患糖尿病的女性比患糖尿病的男性有更多患糖尿病的姐妹。相比之下，患糖尿病的男性在母系或父系的叔伯或姑姑中有糖尿病家庭成员的比例显著高于患糖尿病的女性。有糖尿病母亲的糖尿病患者比例随着年龄增长而下降。在65岁以上的糖尿病患者中，母系效应消失。在65岁以下被诊断为糖尿病的患者中，观察到糖尿病父亲和母亲之间的统计学差异。
我们记录了台湾2型糖尿病中国患者中存在家族聚集和显著的母系遗传现象。需要进一步进行前瞻性研究，以监测糖尿病父母和其他亲属的后代，从而阐明2型糖尿病家族聚集和母系遗传的真正模式。
