Palatsi Riitta, Hägg Päivi
OYS:n ihotautien klinikka.
Duodecim. 2011;127(2):127-34.
The innate and adaptive immune responses have been better understood after the discovery of Toll-like receptors (TLRs), antimicrobial peptides and different populations of dendritic cells. In the skin there are 1 million T-cells per 1 cm2 and 20 billion in total. Naive T-cells activated by antigen-presenting cells can polarize in four directions and they express homing receptor CLA for operating in the skin when the antigen is first detected in the skin area. In psoriasis Th17 activation increases antimicrobial peptides. The IL-23/Th17 axis is largely absent in atopic dermatitis and may result in infections.
在发现Toll样受体（TLRs）、抗菌肽和不同群体的树突状细胞后，人们对先天性和适应性免疫反应有了更深入的了解。皮肤中每平方厘米有100万个T细胞，总数达200亿个。被抗原呈递细胞激活的初始T细胞可向四个方向极化，当在皮肤区域首次检测到抗原时，它们会表达归巢受体CLA以便在皮肤中发挥作用。在银屑病中，Th17激活会增加抗菌肽。特应性皮炎中IL-23/Th17轴基本不存在，这可能导致感染。
