Majeed Muhammed, Bhat Beena, Anand Susmitha, Sivakumar A, Paliwal Pritee, Geetha K G
Sami Labs Limited, Peenya Industrial Area, Bangalore 560058, India.
J Cosmet Sci. 2011 Jan-Feb;62(1):49-56.
As a part of ongoing research for novel natural cosmeceutical actives from plant extracts, this study demonstrates that Phyllanthus emblica fruit extract has shown its efficacy in protection against ultraviolet-B (UVB) irradiation-induced reactive oxygen species (ROS) and collagen damage in normal human dermal fibroblasts. At a concentration of 0.5 mg/ml, emblica extract showed a significant response of 9.5 ± 0.28-fold protection from UVB induced-collagen damage as compared to untreated cells. A known active, ascorbic acid, at a concentration of 0.5 mg/ml, showed 3.7 ± 0.07-fold protection from UVB-induced collagen damage. While the untreated cells showed 84 ± 1.4% induction in ROS on UVB irradiation as compared to the non-irradiated cells, emblica extract treatment inhibited the induction of ROS to 15 ± 4% at a concentration of 0.5 mg/ml. Ascorbic acid inhibited the induction in ROS to 64 ± 2% at a concentration of 0.5 mg/ml. Emblica extract is a significantly better natural active, with promising cosmeceutical benefits against photoaging.
作为从植物提取物中寻找新型天然美容活性成分的一项正在进行的研究的一部分，本研究表明，余甘子果实提取物在保护正常人皮肤成纤维细胞免受紫外线B（UVB）辐射诱导的活性氧（ROS）和胶原蛋白损伤方面显示出功效。在浓度为0.5 mg/ml时，与未处理的细胞相比，余甘子提取物对UVB诱导的胶原蛋白损伤表现出显著的保护作用，保护倍数为9.5±0.28倍。一种已知的活性成分抗坏血酸，在浓度为0.5 mg/ml时，对UVB诱导的胶原蛋白损伤的保护倍数为3.7±0.07倍。与未照射的细胞相比，未处理的细胞在UVB照射下ROS诱导率为84±1.4%，而余甘子提取物处理在浓度为0.5 mg/ml时将ROS诱导率抑制至15±4%。抗坏血酸在浓度为0.5 mg/ml时将ROS诱导率抑制至64±2%。余甘子提取物是一种显著更好的天然活性成分，具有对抗光老化的有前景的美容益处。
