Bilo H J, Gans R O
Department of Internal Medicine, Free University Hospital, Amsterdam, The Netherlands.
Biomed Pharmacother. 1990;44(3):169-74. doi: 10.1016/0753-3322(90)90005-t.
Since the first report by Bang and Dyerberg regarding the apparent beneficial effects of a fish oil-enriched diet on the incidence of atherosclerotic heart disease in Greenland eskimos, a considerable number of studies have been performed regarding the effects of omega-3 polyunsaturated fatty acids on the prevention and treatment of a variety of disease states not necessarily related to atherosclerosis. Studies have been performed on healthy volunteers and in patients with hyperlipidaemia, atherosclerotic vascular disease, diabetes, asthma, psoriasis and chronic renal insufficiency, amongst others. Positive effects on platelet activity, lipid profile, blood rheology and blood pressure--all factors which are presumably of importance in the pathogenesis of atherosclerotic disease have been noted in these studies, albeit with a wide range of variability. Some negative effects also appear to exist. However, some general conclusions can be made regarding the effects of a fish oil-enriched diet.
自从班格（Bang）和戴尔伯格（Dyerberg）首次报道富含鱼油的饮食对格陵兰爱斯基摩人动脉粥样硬化性心脏病发病率具有明显有益作用以来，已经开展了大量关于ω-3多不饱和脂肪酸对预防和治疗各种不一定与动脉粥样硬化相关疾病状态影响的研究。这些研究针对健康志愿者以及高脂血症、动脉粥样硬化性血管疾病、糖尿病、哮喘、银屑病和慢性肾功能不全等患者进行。在这些研究中，已注意到对血小板活性、血脂谱、血液流变学和血压（所有这些因素据推测在动脉粥样硬化性疾病的发病机制中都很重要）有积极影响，尽管存在很大差异。一些负面影响似乎也存在。然而，关于富含鱼油饮食的影响可以得出一些一般性结论。
