von Schacky C
Division of Hematology/Oncology, New York Veterans Administration Medical Center, New York.
Ann Intern Med. 1987 Dec;107(6):890-9. doi: 10.7326/0003-4819-107-6-890.
Traditional approaches to prophylaxis of atherosclerosis have focused on one aspect of the pathogenesis of this multifactorial disease, such as platelet function or blood lipids, and therefore have had limited success. Epidemiologic studies show a striking inverse correlation of consumption of fish rich in the two omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid, and mortality from cardiovascular disease. In studies of volunteers and patients, reductions in platelet responsiveness, lowering of blood lipids, and improvements of blood flow, as well as improvements in other values implicated in the pathogenesis of atherosclerosis, were induced with eicosapentaenoic and docosahexaenoic acids. These findings indicate that these omega-3 fatty acids have a larger prophylactic potential than traditional approaches. This potential must be scrutinized in meticulously designed and conducted trials with clinical endpoints.
传统的动脉粥样硬化预防方法聚焦于这种多因素疾病发病机制的一个方面，比如血小板功能或血脂，因此成效有限。流行病学研究表明，富含二十碳五烯酸和二十二碳六烯酸这两种ω-3脂肪酸的鱼类消费量与心血管疾病死亡率之间存在显著的负相关。在对志愿者和患者的研究中，二十碳五烯酸和二十二碳六烯酸可降低血小板反应性、降低血脂、改善血流，以及改善动脉粥样硬化发病机制中涉及的其他指标。这些发现表明，这些ω-3脂肪酸比传统方法具有更大的预防潜力。这种潜力必须在精心设计和实施的、以临床终点为指标的试验中进行仔细审查。
