Department of Oncology, Complejo Hospitalario de Jaen, Jaen, Spain.
Antioxid Redox Signal. 2011 Aug 15;15(4):903-9. doi: 10.1089/ars.2011.3993. Epub 2011 May 25.
Antineoplastic agents induce oxidative stress leading to lipid, carbohydrate, protein, and DNA damage. We sought to explore the role of drug-induced oxidative stress on breast cancer patient's survival. We observed that neoadjuvant patients presented a marked raise in DNA damage and protein carbonyl levels after chemotherapy, whereas postchemotherapy DNA repair activity of the KU86 enzyme and total antioxidant capacity of the plasma were higher in the adjuvant group. With respect to patient's survival, we observed that increasing levels of KU86 and antioxidant capacity of the plasma during chemotherapy significantly influenced the survival rates of the patients, protecting from disease recurrence and death. Our results suggest that chemotherapy induces a certain level of systemic oxidative stress, which is maintained along successive clinical interventions and could influence the clinical outcome of the patients.
抗肿瘤药物诱导氧化应激，导致脂质、碳水化合物、蛋白质和 DNA 损伤。我们试图探讨药物诱导的氧化应激对乳腺癌患者生存的影响。我们观察到，新辅助化疗后患者的 DNA 损伤和蛋白质羰基水平明显升高，而辅助化疗组的 KU86 酶的 DNA 修复活性和血浆总抗氧化能力更高。就患者的生存而言，我们观察到化疗过程中 KU86 和血浆抗氧化能力的水平升高与患者的生存率显著相关，可预防疾病复发和死亡。我们的研究结果表明，化疗会引起一定程度的全身氧化应激，这种应激会在连续的临床干预中维持，并可能影响患者的临床结局。
