Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23284, USA.
J Dent Res. 2011 Oct;90(10):1155-63. doi: 10.1177/0022034511402994. Epub 2011 Mar 29.
In the healthy subgingiva, oral treponemes account for a small percentage of the total bacteria. However, in diseased periodontal pockets, treponemes thrive and become a dominant component of the bacterial population. Oral treponemes are uniquely adept at capitalizing on the environmental conditions that develop with periodontal disease. The molecular basis of adaptive responses of oral treponemes is just beginning to be investigated and defined. The completion of several treponeme genome sequences and the characterization of global regulatory systems provide an important starting point in the analysis of signaling and adaptive responses. In this review, we discuss existing literature focused on the genetic regulatory mechanisms of Treponema denticola and present an overview of the possible roles of regulatory proteins identified through genome analyses. This information provides insight into the possible molecular mechanisms utilized by oral spirochetes to survive in the periodontal pocket and transition from a minor to a dominant organism.
在健康的牙周袋中，口腔密螺旋体仅占总细菌的一小部分。然而，在患病的牙周袋中，密螺旋体大量繁殖并成为细菌种群的主要组成部分。口腔密螺旋体特别擅长利用牙周病发展过程中形成的环境条件。口腔密螺旋体适应性反应的分子基础才刚刚开始被研究和确定。完成几个密螺旋体基因组序列的测序以及对全局调控系统的描述为分析信号转导和适应性反应提供了重要的起点。在这篇综述中，我们讨论了现有文献中关于牙髓密螺旋体的遗传调控机制，并概述了通过基因组分析鉴定的可能发挥作用的调控蛋白。这些信息为理解口腔螺旋体在牙周袋中生存并从次要生物转变为主要生物的可能分子机制提供了线索。
