University of Washington, Seattle, Washington 98195, USA.
Nat Rev Microbiol. 2010 Jul;8(7):481-90. doi: 10.1038/nrmicro2337.
Periodontitis, or gum disease, affects millions of people each year. Although it is associated with a defined microbial composition found on the surface of the tooth and tooth root, the contribution of bacteria to disease progression is poorly understood. Commensal bacteria probably induce a protective response that prevents the host from developing disease. However, several bacterial species found in plaque (the 'red-complex' bacteria: Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola) use various mechanisms to interfere with host defence mechanisms. Furthermore, disease may result from 'community-based' attack on the host. Here, I describe the interaction of the host immune system with the oral bacteria in healthy states and in diseased states.
牙周炎，或牙龈疾病，每年影响数百万人。虽然它与牙齿和牙根表面发现的特定微生物组成有关，但细菌对疾病进展的贡献还不清楚。共生细菌可能会诱导一种保护反应，使宿主不会患上疾病。然而，在斑块中发现的几种细菌（“红色复合体”细菌：牙龈卟啉单胞菌、福赛斯坦纳菌和牙髓密螺旋体）使用各种机制来干扰宿主防御机制。此外，疾病可能是由对宿主的“基于社区的”攻击引起的。在这里，我描述了宿主免疫系统与口腔细菌在健康状态和疾病状态下的相互作用。
