用于细胞内成像和抗癌药物递送的生物相容、表面功能化介孔二氧化钛纳米颗粒。
Biocompatible, surface functionalized mesoporous titania nanoparticles for intracellular imaging and anticancer drug delivery.
机构信息
Department of Chemical Engineering, National Taiwan University. No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
出版信息
Chem Commun (Camb). 2011 May 14;47(18):5232-4. doi: 10.1039/c1cc10659g. Epub 2011 Mar 31.
Mesoporous titania nanoparticles (MTNs) with excellent biocompatibility (LC(50)≈ 400 μg mL(-1)) and a large surface area (ca. 237.3 m(2) g(-1)) were synthesized and further functionalized with a phosphate-containing fluorescent molecule (i.e. flavin mononucleotide; FMN) and loaded with an anticancer drug (i.e. Doxorubicin) for successful intracellular bioimaging and drug delivery, respectively, in human breast cancer cells BT-20.
介孔二氧化钛纳米粒子（MTNs）具有极好的生物相容性（LC(50)≈400μg mL(-1))和较大的表面积（约 237.3 m(2) g(-1)))，被合成后进一步用含磷酸盐的荧光分子（即黄素单核苷酸；FMN）功能化，并装载抗癌药物（即多柔比星），分别成功地用于人乳腺癌细胞 BT-20 中的细胞内生物成像和药物传递。
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