University of Michigan School of Social Work, 1080 S University, Ann Arbor, MI 48109-1106, USA.
Qual Life Res. 2011 Dec;20(10):1595-608. doi: 10.1007/s11136-011-9893-8. Epub 2011 Mar 31.
To examine whether childhood cancer survivors' perceptions of the impact of cancer are related to quality of life (QOL) and psychological distress.
621 survivors (aged 18-39 years) completed a mailed survey assessing distress and QOL. Hierarchical linear regression models analyzed the independent effects of perceived impacts of cancer on distress and QOL and the extent to which positive and negative perceptions attenuated the effects of covariates on outcomes.
After accounting for perceptions of cancer's impact on their lives, employment/occupation status, marital/relationship status, and health problems were observed to be significant predictors of QOL and distress. Psychological distress and the mental health component of QOL appeared to be less influenced by sociodemographic status and health problems and more a function of how survivors perceive cancer as impacting their lives.
Results suggest that distress and QOL are partially a function of survivors' perceptions of how cancer has affected them and continues to affect them in both positive and negative ways. Future research is needed to examine combinations of pharmacological, psychological and/or social interventions that are likely to result in better outcomes in this population.
探讨儿童癌症幸存者对癌症影响的认知是否与生活质量（QOL）和心理困扰有关。
621 名幸存者（18-39 岁）完成了一项邮寄调查，评估了困扰和 QOL。分层线性回归模型分析了癌症对困扰和 QOL 的独立影响，以及积极和消极认知对结局的协变量影响的减弱程度。
在考虑了癌症对生活的影响后，就业/职业状况、婚姻/关系状况和健康问题被观察到是 QOL 和困扰的重要预测因素。心理困扰和 QOL 的心理健康成分似乎较少受到社会人口统计学状况和健康问题的影响，而更多地取决于幸存者对癌症如何影响他们生活的认知。
结果表明，困扰和 QOL 在一定程度上是幸存者对癌症如何影响他们以及癌症以积极和消极方式继续影响他们的认知的结果。未来需要研究可能导致这一人群更好结果的药物治疗、心理和/或社会干预的组合。
