微生物源乙酰胆碱酯酶抑制剂的研究进展与检测方法：系统综述
Research Advances and Detection Methodologies for Microbe-Derived Acetylcholinesterase Inhibitors: A Systemic Review.
作者信息
Su Jingqian, Liu Huiying, Guo Kai, Chen Long, Yang Minhe, Chen Qi
机构信息
Fujian Key Laboratory of Innate Immune Biology, Fujian Normal University, Fuzhou 350117, China.
Biomedical Research Center of South China, Fujian Normal University, Fuzhou 350117, China.
出版信息
Molecules. 2017 Jan 23;22(1):176. doi: 10.3390/molecules22010176.
Acetylcholinesterase inhibitors (AChEIs) are an attractive research subject owing to their potential applications in the treatment of neurodegenerative diseases. Fungi and bacteria are major producers of AChEIs. Their active ingredients of fermentation products include alkaloids, terpenoids, phenylpropanoids, and steroids. A variety of in vitro acetylcholinesterase inhibitor assays have been developed and used to measure the activity of acetylcholinesterases, including modified Ellman's method, thin layer chromatography bioautography, and the combined liquid chromatography-mass spectrometry/modified Ellman's method. In this review, we provide an overview of the different detection methodologies, the microbe-derived AChEIs, and their producing strains.
乙酰胆碱酯酶抑制剂（AChEIs）因其在神经退行性疾病治疗中的潜在应用而成为一个有吸引力的研究课题。真菌和细菌是AChEIs的主要生产者。其发酵产物的活性成分包括生物碱、萜类化合物、苯丙素类化合物和甾体化合物。已经开发了多种体外乙酰胆碱酯酶抑制剂测定方法并用于测量乙酰胆碱酯酶的活性，包括改良的埃尔曼方法、薄层色谱生物自显影法以及液相色谱-质谱联用/改良的埃尔曼方法。在本综述中，我们概述了不同的检测方法、微生物来源的AChEIs及其生产菌株。
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