Section for Preventive Medicine and Epidemiology, Institute of Health and Society, University of Oslo, Oslo, Norway.
High Alt Med Biol. 2011 Spring;12(1):57-63. doi: 10.1089/ham.2010.1050.
The aim of this study was to determine the prevalence of abnormal lipid levels and its association with selected coronary heart disease (CHD) risk factors in the Tibetan population living at 3660 meters above sea level in Lhasa, Tibet. Three hundred seventy one randomly selected male and female, aged 30 to 70 yr took part in the study. Based on the National Cholesterol Education Programme (NCED) adult treatment panel ATP-III 2004 criteria, the age-adjusted prevalence of hypertriglyceridemia was 12.0%; high triglycerides (TG), 33.4%; high low-density lipoprotein cholesterol (LDL-C), 4.8%; and low high-density lipoprotein cholesterol (HDL-C); 24.3%. After adjusting for age, sex, smoking, alcohol, physical activity, diet, hemoglobin (Hb) concentration, and systolic and diastolic blood pressure (BP), an increase in waist-to-hip ratio (WHR) by 0.1 unit was associated with a statistically significant increase in TG, total cholesterol (TC) and LDL-C by 0.25 mmol/L, 0.24 mmol/L, and 0.18 mmol/L, respectively. Female gender increased HDL-C by 0.18 mmol/L when compared with males. Age-adjusted prevalences of Framingham CHD risk score for males and females were 16.3% and 0.6%, respectively. This study demonstrated a high prevalence of hypertriglyceridemia in males, a higher prevalence of low HDL-C in females, and a high hypercholesterolemia prevalence in both genders. However, further longitudinal studies assessing CHD risk factors in high altitude natives are required.
本研究旨在确定拉萨海拔 3660 米的藏民脂质水平异常的患病率及其与冠心病（CHD）危险因素的相关性。371 名 30 至 70 岁的随机男女参加了这项研究。根据国家胆固醇教育计划（NCEP）成人治疗小组 ATP-III 2004 标准，校正年龄后的高甘油三酯血症患病率为 12.0%；高甘油三酯（TG）为 33.4%；低高密度脂蛋白胆固醇（HDL-C）为 4.8%；低高密度脂蛋白胆固醇（HDL-C）为 24.3%。校正年龄、性别、吸烟、饮酒、体力活动、饮食、血红蛋白（Hb）浓度、收缩压和舒张压（BP）后，腰臀比（WHR）增加 0.1 单位与 TG、总胆固醇（TC）和 LDL-C 分别显著增加 0.25mmol/L、0.24mmol/L 和 0.18mmol/L 相关。与男性相比，女性的 HDL-C 增加了 0.18mmol/L。男性和女性Framingham CHD 风险评分的校正年龄患病率分别为 16.3%和 0.6%。本研究表明，男性高甘油三酯血症患病率较高，女性低 HDL-C 患病率较高，两性高胆固醇血症患病率较高。然而，还需要进一步的纵向研究来评估高海拔居民的 CHD 危险因素。
