Center for Cancer Prevention and Detection, Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea.
Obesity (Silver Spring). 2014 Feb;22(2):518-25. doi: 10.1002/oby.20390. Epub 2013 Jun 11.
This study aimed to examine the association between obesity and the risk of colorectal adenomatous polyps.
The design of this study is a cross-sectional study. A total of 1,574 participants (818 males and 756 females), who had undergone colonoscopy for health examinations at the National Cancer Center hospital in South Korea from February to September 2009, were included in the analysis.
The prevalence of colorectal adenomatous polyps was 39.5% in males and 22.6% in females. In multiple logistic regression analysis, obesity (odds ratio [OR] = 1.69, 95% CI = 1.16-2.48) and abdominal obesity (OR = 1.59, 95% CI = 1.13-2.23) were significantly associated with an increased risk of colorectal adenomatous polyps in males, but not in females. In the subgroup analyses by age, obesity (OR = 2.27, 95% CI = 1.32-3.89), and abdominal obesity (OR = 1.76, 95% CI = 1.12-2.76) significantly increased a risk of colorectal adenomatous polyps in males aged <50 years, but not in males aged ≥50 years. However, interaction terms were not significant between obesity and gender (P = 0.397) and between obesity and age (P = 0.531) in the overall analyses.
Our findings should be explored in further research.
本研究旨在探讨肥胖与结直肠腺瘤性息肉风险之间的关联。
本研究的设计为横断面研究。共纳入 2009 年 2 月至 9 月期间在韩国国家癌症中心医院因健康检查而行结肠镜检查的 1574 名参与者（818 名男性和 756 名女性）。
男性结直肠腺瘤性息肉的患病率为 39.5%，女性为 22.6%。在多因素 logistic 回归分析中，肥胖（比值比 [OR] = 1.69，95%可信区间 [CI] = 1.16-2.48）和腹型肥胖（OR = 1.59，95%CI = 1.13-2.23）与男性结直肠腺瘤性息肉风险增加显著相关，但在女性中无此相关性。在按年龄分层的亚组分析中，肥胖（OR = 2.27，95%CI = 1.32-3.89）和腹型肥胖（OR = 1.76，95%CI = 1.12-2.76）显著增加了男性 <50 岁人群结直肠腺瘤性息肉的风险，但在男性≥50 岁人群中则无此相关性。然而，在总体分析中，肥胖与性别（P = 0.397）和肥胖与年龄（P = 0.531）之间的交互作用项无统计学意义。
需要进一步研究来探讨我们的发现。
