Dept of Interdisciplinary Social Science, University of Utrecht, PO Box 80.140, 3508 TC Utrecht, The Netherlands.
Schizophr Res. 2011 Aug;130(1-3):277-81. doi: 10.1016/j.schres.2011.03.003. Epub 2011 Apr 1.
The path from subclinical psychotic experiences to clinical disorder is thought to be mediated by the persistence of subclinical psychotic experiences. One of the factors that is likely associated with this persistence is depression. Although commonly viewed as interrelated concepts, the exact relationship between subclinical psychosis and depression is not clear.
Cross-lagged path modeling was used to explore the relationship between subclinical psychosis and depression across and over time in an adolescent population seeking assistance for non-psychotic disorders (N=138), measured at four occasions over a two-year period.
Subclinical psychosis and depression were related to each other at every cross-sectional measurement, but did not predict each other over time. Subclinical psychotic experiences and depressive symptom levels were highest at baseline, when participants presented to the clinical service for help. In addition, the relationship between them was also strongest at baseline and decreased significantly over time.
The results suggest that psychosis and depression are interrelated phenomena that strongly co-occur in time, but longitudinally, one does not predict change in the other. Both psychopathological dimensions should be addressed when treatment is provided to adolescent help-seekers.
从亚临床精神病体验到临床障碍的转变过程被认为是由亚临床精神病体验的持续存在所介导的。可能与这种持续存在相关的因素之一是抑郁。尽管通常被视为相互关联的概念，但亚临床精神病和抑郁之间的确切关系尚不清楚。
在一个寻求非精神病障碍帮助的青少年人群中（N=138），使用跨期路径建模方法来探索在两年的四个时间点上，亚临床精神病和抑郁之间的关系。
亚临床精神病和抑郁在每一个横断面测量中都相互关联，但在时间上没有相互预测。亚临床精神病体验和抑郁症状水平在基线时最高，此时参与者到临床服务机构寻求帮助。此外，它们之间的关系也在基线时最强，随着时间的推移显著下降。
研究结果表明，精神病和抑郁是相互关联的现象，它们在时间上强烈地同时发生，但从纵向来看，两者之间并没有相互预测。在为青少年求助者提供治疗时，应同时关注这两个病理维度。
