• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

生物膜解体剂会上市吗?

Will biofilm disassembly agents make it to market?

机构信息

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Trends Microbiol. 2011 Jul;19(7):304-6. doi: 10.1016/j.tim.2011.03.003. Epub 2011 Mar 31.

DOI:10.1016/j.tim.2011.03.003
PMID:21458996
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3750235/
Abstract

Nearly 12 years after promising results suggested that antibiofilm agents might be developed into novel therapeutics, there are no such products on the market. In our opinion, the reasons for this have been predominantly economic. Recent developments, however, suggest that there could still be emerging opportunities for the developments of such products.

摘要

近 12 年前,有研究结果表明,抗生物膜剂可能被开发成新型疗法,此后便再无相关进展。在我们看来,这主要是出于经济方面的考虑。然而,最近的一些发展表明,此类产品的开发仍可能会出现新的机遇。

相似文献

1
Will biofilm disassembly agents make it to market?生物膜解体剂会上市吗?
Trends Microbiol. 2011 Jul;19(7):304-6. doi: 10.1016/j.tim.2011.03.003. Epub 2011 Mar 31.
2
Agents that inhibit bacterial biofilm formation.抑制细菌生物膜形成的制剂。
Future Med Chem. 2015;7(5):647-71. doi: 10.4155/fmc.15.7.
3
Biofilms: prevention and treatment.生物膜:预防与治疗
Br J Hosp Med (Lond). 2016 Dec 2;77(12):699-703. doi: 10.12968/hmed.2016.77.12.699.
4
Eradication of Microorganisms Embedding in Biofilm by a Dose-Dependent Urokinase-Based Catheter Lock Solution in Chronic Hemodialysis Patients.基于尿激酶的导管封管液对慢性血液透析患者生物膜内定植微生物的剂量依赖性清除作用。
Blood Purif. 2020;49(5):586-596. doi: 10.1159/000505566. Epub 2020 Jan 14.
5
Antibiotic Lock in Tenckhoff Catheter for Biofilm-Associated Peritonitis.Tenckhoff导管抗生素封管治疗生物膜相关腹膜炎
Perit Dial Int. 2017 Jul-Aug;37(4):475-477. doi: 10.3747/pdi.2016.00252.
6
Biofilm and catheter-related bloodstream infections.生物膜与导管相关血流感染。
Br J Nurs. 2021 Apr 22;30(8):S4-S9. doi: 10.12968/bjon.2021.30.8.S4.
7
Development of broad-spectrum antibiofilm drugs: strategies and challenges.广谱抗生物膜药物的研发:策略与挑战
Future Microbiol. 2015;10(6):1035-48. doi: 10.2217/fmb.15.14.
8
Full and broad-spectrum in vivo eradication of catheter-associated biofilms using gentamicin-EDTA antibiotic lock therapy.使用庆大霉素-EDTA 抗生素封管疗法实现充分且广谱的体内消除导管相关生物膜。
Antimicrob Agents Chemother. 2012 Dec;56(12):6310-8. doi: 10.1128/AAC.01606-12. Epub 2012 Oct 1.
9
Antibiofilm agents and implant-related infections in orthopaedics: where are we?骨科领域的抗生物膜药物与植入物相关感染:我们目前的进展如何?
J Chemother. 2013 Apr;25(2):67-80. doi: 10.1179/1973947812Y.0000000045.
10
Something old, something new: revisiting natural products in antibiotic drug discovery.旧药新用:重新审视天然产物在抗生素药物研发中的作用。
Can J Microbiol. 2014 Mar;60(3):147-54. doi: 10.1139/cjm-2014-0063. Epub 2014 Jan 22.

引用本文的文献

1
Sophorolipid: An Effective Biomolecule for Targeting Microbial Biofilms.槐糖脂:一种针对微生物生物膜的有效生物分子。
Curr Microbiol. 2024 Oct 4;81(11):388. doi: 10.1007/s00284-024-03892-6.
2
An Overview of Biofilm Formation-Combating Strategies and Mechanisms of Action of Antibiofilm Agents.生物膜形成的对抗策略及抗生物膜剂作用机制概述
Life (Basel). 2022 Jul 23;12(8):1110. doi: 10.3390/life12081110.
3
Graphene oxide decorated with zinc oxide nanoflower, silver and titanium dioxide nanoparticles: fabrication, characterization, DNA interaction, and antibacterial activity.氧化锌纳米花、银和二氧化钛纳米颗粒修饰的氧化石墨烯:制备、表征、DNA相互作用及抗菌活性
RSC Adv. 2019 Jan 28;9(7):3704-3714. doi: 10.1039/c8ra09788g. eCollection 2019 Jan 25.
4
Fostering Innovation in the Treatment of Chronic Polymicrobial Cystic Fibrosis-Associated Infections Exploring Aspartic Acid and Succinic Acid as Ciprofloxacin Adjuvants.促进慢性多微生物囊性纤维化相关感染治疗中的创新:探索天冬氨酸和琥珀酸作为环丙沙星佐剂
Front Cell Infect Microbiol. 2020 Aug 27;10:441. doi: 10.3389/fcimb.2020.00441. eCollection 2020.
5
Amyloid-Like β-Aggregates as Force-Sensitive Switches in Fungal Biofilms and Infections.淀粉样β-聚集物作为真菌生物膜和感染中的力敏开关。
Microbiol Mol Biol Rev. 2017 Nov 29;82(1). doi: 10.1128/MMBR.00035-17. Print 2018 Mar.
6
Multiple Dictyostelid Species Destroy Biofilms of Klebsiella oxytoca and Other Gram Negative Species.多种盘基网柄菌属物种可破坏产酸克雷伯菌及其他革兰氏阴性菌的生物膜。
Protist. 2017 Jul;168(3):311-325. doi: 10.1016/j.protis.2017.04.001. Epub 2017 Apr 12.
7
Advances in the treatment of problematic industrial biofilms.工业有害生物膜处理方法的进展
World J Microbiol Biotechnol. 2017 May;33(5):97. doi: 10.1007/s11274-016-2203-4. Epub 2017 Apr 13.
8
Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action.对抗细菌生物膜的策略:聚焦于抗生物膜剂及其作用机制。
Virulence. 2018 Jan 1;9(1):522-554. doi: 10.1080/21505594.2017.1313372.
9
Microbial Biofilms and Chronic Wounds.微生物生物膜与慢性伤口
Microorganisms. 2017 Mar 7;5(1):9. doi: 10.3390/microorganisms5010009.
10
Marine Sponge-Derived sp. SBT343 Extract Inhibits Staphylococcal Biofilm Formation.源自海洋海绵的sp. SBT343提取物可抑制葡萄球菌生物膜形成。
Front Microbiol. 2017 Feb 16;8:236. doi: 10.3389/fmicb.2017.00236. eCollection 2017.

本文引用的文献

1
Biofilms.生物膜。
Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a000398. doi: 10.1101/cshperspect.a000398. Epub 2010 Jun 2.
2
D-amino acids trigger biofilm disassembly.D-氨基酸引发生物膜解体。
Science. 2010 Apr 30;328(5978):627-9. doi: 10.1126/science.1188628.
3
Biofilm dispersal: mechanisms, clinical implications, and potential therapeutic uses.生物膜分散:机制、临床意义及潜在治疗用途。
J Dent Res. 2010 Mar;89(3):205-18. doi: 10.1177/0022034509359403. Epub 2010 Feb 5.
4
National Healthcare Safety Network (NHSN) report: data summary for 2006 through 2008, issued December 2009.国家医疗安全网络(NHSN)报告:2006年至2008年数据摘要,2009年12月发布。
Am J Infect Control. 2009 Dec;37(10):783-805. doi: 10.1016/j.ajic.2009.10.001.
5
Intravascular catheter infections.血管内导管感染。
J Hosp Infect. 2009 Dec;73(4):323-30. doi: 10.1016/j.jhin.2009.05.008. Epub 2009 Aug 22.
6
Controlling bacterial biofilms.控制细菌生物膜
Chembiochem. 2009 Sep 21;10(14):2287-94. doi: 10.1002/cbic.200900317.
7
The sea-surface microlayer is a gelatinous biofilm.海面微层是一种凝胶状生物膜。
ISME J. 2009 Sep;3(9):1001-3. doi: 10.1038/ismej.2009.69. Epub 2009 Jun 25.
8
Signals, regulatory networks, and materials that build and break bacterial biofilms.构建和破坏细菌生物膜的信号、调控网络及物质。
Microbiol Mol Biol Rev. 2009 Jun;73(2):310-47. doi: 10.1128/MMBR.00041-08.
9
Preventing biofilms of clinically relevant organisms using bacteriophage.利用噬菌体预防临床相关微生物的生物膜形成。
Trends Microbiol. 2009 Feb;17(2):66-72. doi: 10.1016/j.tim.2008.11.002. Epub 2009 Jan 21.
10
Microbial sciences: the superficial life of microbes.微生物科学:微生物的表层生命
Nature. 2006 May 18;441(7091):300-2. doi: 10.1038/441300a.