Vatten L J, Kvinnsland S
Department of Oncology, University Hospital, Trondheim, Norway.
Eur J Cancer. 1990;26(7):830-3. doi: 10.1016/0277-5379(90)90164-o.
The association between cigarette smoking and incidence of breast cancer has been analyzed in 242 cases of breast cancer that developed among 24,329 Norwegian women over 11-14 years of follow-up. At baseline they were aged 35-51. There was no overall association between cigarette smoking and the risk of breast cancer. The age-adjusted incidence rate ratio (IRR) was unity (IRR = 1.04, 95% CI 0.76-1.42) for regular smokers (10 or more cigarettes daily) compared with non-smoking women. In women who reported smoking between 1 and 9 cigarettes per day there was an age-adjusted IRR of 1.28 (95% CI 0.95-1.73). The lack of association with cigarette smoking was replicated in subgroup analyses of women diagnosed before age 51 ("premenopausal") and among women diagnosed after this age ("postmenopausal"). However, there was a significant interaction between cigarette smoking, body mass index and age at diagnosis (P = 0.01), which might indicate that an interaction between cigarette smoking and body mass exerts differential effects on breast cancer risk in premenopausal and postmenopausal women.
在对24329名挪威女性进行11至14年随访期间发生的242例乳腺癌病例中，分析了吸烟与乳腺癌发病率之间的关联。在基线时，她们的年龄为35至51岁。吸烟与患乳腺癌风险之间没有总体关联。与不吸烟女性相比，经常吸烟者（每天吸10支或更多香烟）的年龄调整发病率比（IRR）为1.0（IRR = 1.04，95%置信区间0.76 - 1.42）。在报告每天吸1至9支香烟的女性中，年龄调整后的IRR为1.28（95%置信区间0.95 - 1.73）。在51岁之前被诊断出的女性（“绝经前”）和在此年龄之后被诊断出的女性（“绝经后”）的亚组分析中，吸烟与乳腺癌缺乏关联这一结果得到了重复。然而，吸烟、体重指数与诊断时年龄之间存在显著的交互作用（P = 0.01），这可能表明吸烟与体重指数之间的交互作用对绝经前和绝经后女性的乳腺癌风险产生了不同的影响。
