Vatten L J, Kvinnsland S
Department of Oncology, University Hospital, Trondheim, Norway.
Int J Cancer. 1990 Mar 15;45(3):440-4. doi: 10.1002/ijc.2910450311.
The association between body mass index (BMI) and the incidence rate of breast cancer has been examined in 236 cases of breast cancer that developed among 23,826 Norwegian women during 11 to 14 years of follow-up. At the time of height and weight measurement they were 35 to 51 years of age, and at the end of follow-up their age was between 46 and 63 years. There was an overall age-adjusted incidence rate ratio (IRR) of 0.52 (95% confidence limits, 0.34 and 0.77) for women in the highest quartile of BMI compared to women in the lowest quartile, which was confined to an effect observed among women who were diagnosed at age 50 or earlier (IRR = 0.36). The association with BMI displayed an inverse dose-related trend (chi 2 for trend = 14.22, p less than 0.001). The negative trend was particularly pronounced among non-smoking women (chi 2 = 14.63), and no clear trend associate with BMI was observed among women who smoked 10 or more cigarettes per day (chi 2 = 0.41), indicating an interaction between BMI and cigarette smoking (chi 2 interaction = 3.86, p = 0.05). We thus suggest that there is a negative association between body mass index and risk of breast cancer among premenopausal women.
在对23826名挪威女性进行11至14年随访期间，共出现236例乳腺癌病例，研究人员对体重指数（BMI）与乳腺癌发病率之间的关联进行了调查。在测量身高和体重时，她们的年龄在35至51岁之间，随访结束时年龄在46至63岁之间。与BMI最低四分位数的女性相比，BMI最高四分位数的女性总体年龄调整发病率比（IRR）为0.52（95%置信区间为0.34和0.77），这种关联仅限于50岁及更早被诊断出乳腺癌的女性（IRR = 0.36）。BMI之间的关联呈现出剂量相关的负向趋势（趋势χ² = 14.22，p < 0.001）。这种负向趋势在不吸烟女性中尤为明显（χ² = 14.63），而在每天吸烟10支及以上的女性中未观察到与BMI的明显趋势关联（χ² = 0.41），这表明BMI与吸烟之间存在相互作用（交互作用χ² = 3.86，p = 0.05）。因此，我们认为绝经前女性的体重指数与乳腺癌风险之间存在负相关。
