Mahbub Shegufta, Brubaker Aleah L, Kovacs Elizabeth J
The Burn and Shock Trauma Institute, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA.
Curr Immunol Rev. 2011 Feb 1;7(1):104-115. doi: 10.2174/157339511794474181.
The relationship between advanced age and immunologic deficits is becoming an area of rapidly advancing research. Many of the clinical hurdles in the elderly population result from dysregulation of the immune system leading to the inability of the elderly to swiftly combat infection and to the increased incidence of chronic disease states and autoimmune conditions. Herein, we address the crucial alterations in the innate immune system that occur with advancing age. Specifically, we discuss how the effects of advanced age may lead to functional changes in the neutrophil, macrophage, dendritic cell, natural killer cell, and natural killer T cell populations in human and murine models that translate into aberrant innate immune responses. Furthermore, we elucidate how these changes may contribute to documented deficits in adaptive immunity as well as the pathological conditions and the increased morbidity and mortality seen in the elderly population.
高龄与免疫缺陷之间的关系正成为一个研究进展迅速的领域。老年人群中的许多临床障碍是由免疫系统失调导致的，这使得老年人无法迅速抵抗感染，并导致慢性病状态和自身免疫性疾病的发病率增加。在此，我们探讨随着年龄增长，先天免疫系统发生的关键变化。具体而言，我们讨论了高龄的影响如何导致人类和小鼠模型中中性粒细胞、巨噬细胞、树突状细胞、自然杀伤细胞和自然杀伤T细胞群体的功能变化，这些变化转化为异常的先天免疫反应。此外，我们阐明了这些变化如何导致适应性免疫方面已记录的缺陷，以及老年人群中出现的病理状况、发病率和死亡率增加的情况。
