The Burn and Shock Trauma Institute, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA.
Aging Dis. 2011 Oct;2(5):346-60. Epub 2011 Oct 28.
In the elderly patient population, it has become increasingly evident that immune dysregulation is a contributing factor to age-related pathologies and their associated morbidity and mortality. In particular, elderly subjects are plagued by poor responses to infectious challenge and immunization and are at heightened risk for the development of autoimmune, neuroinflammatory and tumor-associated pathologies. Rodent models of aging and age-related disorders have been utilized to better describe how innate immune cell dysfunction contributes to these clinical scenarios. As the elderly population continues to increase in size, use of these aging rodent models to study immune dysregulation may translate into increased healthy living years for these individuals.
在老年患者群体中，免疫失调是导致与年龄相关的病理及其相关发病率和死亡率的一个重要因素，这一点变得越来越明显。特别是，老年患者对感染性挑战和免疫接种的反应较差，并且更容易发生自身免疫、神经炎症和与肿瘤相关的病理。已经利用衰老和与年龄相关疾病的啮齿动物模型来更好地描述固有免疫细胞功能障碍如何导致这些临床情况。随着老年人口的持续增加，使用这些衰老啮齿动物模型来研究免疫失调可能会使这些人增加健康的生活年限。
