School of Chemical Engineering, Sichuan University, Chengdu, China.
Lab Chip. 2011 May 7;11(9):1587-92. doi: 10.1039/c1lc20065h. Epub 2011 Apr 1.
A hierarchical and scalable microfluidic device constructed from a combination of three building blocks enables highly controlled generation of multicomponent multiple emulsions. The number, ratio and size of droplets, each with distinct contents being independently co-encapsulated in the same level, can be precisely controlled. The building blocks are a drop maker, a connector and a liquid extractor; combinations of these enable the scale-up of the device to create higher-order multicomponent multiple emulsions with exceptionally diverse structures. These multicomponent multiple emulsions offer a versatile and promising platform for precise encapsulation of incompatible actives or chemicals, for synergistic delivery and biochemical and chemical reactions, and for engineering multicompartment materials with controlled internal phases.
一种由三个构建块组合而成的分层和可扩展的微流控装置，能够高度精确地生成多组分多乳液。可以精确控制每个液滴的数量、比例和大小，并且每个液滴都具有不同的内容物，被独立地共同包封在同一级别中。这些构建块是一个液滴生成器、一个连接器和一个液体提取器；这些构建块的组合可以实现装置的规模化，以创建具有异常多样结构的更高阶的多组分多乳液。这些多组分多乳液为精确封装不相容的活性剂或化学品、协同输送以及生化和化学反应，以及工程具有受控内部相的多腔材料提供了一个多功能且有前途的平台。
