如何成为有丝分裂染色体。
How to be a mitotic chromosome.
机构信息
Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.
出版信息
Chromosome Res. 2011 Apr;19(3):307-19. doi: 10.1007/s10577-011-9198-3.
Abstract
Proper mitotic chromosome structure is essential for faithful chromosome segregation. Mounting evidence suggests that mitotic chromosome assembly is a progressive, dynamic process that requires topoisomerase II, condensins and cohesin and the activity of several signalling molecules. Current results suggest how these different activities might interact to achieve the familiar form of the mitotic chromosome.
摘要
正确的有丝分裂染色体结构对于忠实的染色体分离至关重要。越来越多的证据表明，有丝分裂染色体组装是一个渐进的、动态的过程，需要拓扑异构酶 II、凝聚素和黏合蛋白以及几种信号分子的活性。目前的结果表明，这些不同的活性如何相互作用以实现有丝分裂染色体的常见形式。
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