Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan.
Ethn Dis. 2011 Winter;21(1):74-8.
Metabolic syndrome (MetS) is associated with chronic inflammation and cardiovascular disease. The present study's aim was to investigate the relationship between serum C-reactive protein (CRP) and MetS in the Mongolian population in comparison to the Japanese population.
Two-hundred and eighty-five Mongolian volunteers (males/females: 115/170, mean age 44.9 years) and 326 Japanese volunteers (males/females: 137/189, mean age 43.6 years) were recruited from health check-up settings. Cardiometabolic variables including CRP were measured. The patients were divided into three groups by the number of MetS risk factors (< 1, 1-2 or > or = 3).
The percentages of patients with MetS were 39.6% in the Mongolians and 31.1% in the Japanese. The median CRP levels were .05, .12 and .19 mg/dL in the < 1, 1-2 and > or =3 MetS risk factor groups among Mongolians, and .03, .05 and .07 mg/dL in these same groups among Japanese. The significance for the trend for CRP levels within each ethnic group was P < .001, and the significance for the difference in CRP levels between the respective groups by the MetS risk factors was P = .03 in subjects with < 1, P < .001 in subjects with 1-2, P < .001 in subjects with > or = 3. These results were similar in the subgroup analyses by sex.
While higher serum CRP levels were seen with increased MetS risk factors in both ethnic groups, in some cases we observed a higher serum CRP level increase in the Mongolian population than in the Japanese population. Mongolian people may be at greater risk for cardiovascular disease.
代谢综合征（MetS）与慢性炎症和心血管疾病有关。本研究旨在比较蒙古族人群和日本人群血清 C 反应蛋白（CRP）与 MetS 的关系。
从健康检查中招募了 285 名蒙古族志愿者（男/女：115/170，平均年龄 44.9 岁）和 326 名日本志愿者（男/女：137/189，平均年龄 43.6 岁）。测量了包括 CRP 在内的心血管代谢变量。根据 MetS 危险因素的数量（<1、1-2 或≥3）将患者分为三组。
蒙古族患者中 MetS 的比例为 39.6%，日本患者为 31.1%。蒙古族患者中 CRP 水平中位数分别为<1、1-2 和≥3 个 MetS 危险因素组为 0.05、0.12 和 0.19mg/dL，而日本患者分别为 0.03、0.05 和 0.07mg/dL。每个种族组内 CRP 水平趋势的显著性为 P<0.001，各组之间 CRP 水平的显著性差异为 P=0.03（<1 个危险因素），P<0.001（1-2 个危险因素），P<0.001（≥3 个危险因素）。按性别进行亚组分析时，结果相似。
虽然两个种族群体的 MetS 危险因素增加时，血清 CRP 水平升高，但在某些情况下，我们观察到蒙古族人群的血清 CRP 水平升高幅度高于日本人群。蒙古族人群患心血管疾病的风险可能更高。
