动力相关蛋白 DRP-1 与胰岛素信号通路协同调节秀丽隐杆线虫的寿命。
The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity.
机构信息
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
出版信息
Aging Cell. 2011 Aug;10(4):724-8. doi: 10.1111/j.1474-9726.2011.00711.x. Epub 2011 Apr 25.
Abstract
Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.
摘要
在这里，我们报告说，秀丽隐杆线虫中与动力蛋白相关的蛋白 DRP-1 的失活，这种蛋白是负责线粒体分裂的关键组成部分，从酵母到人类都保守存在，它极大地增强了降低胰岛素信号（IIS）的效果，从而延长了寿命。这代表了操纵线粒体动力学对动物寿命产生有益影响的第一个报告，并表明线粒体形态和 IIS 共同调节衰老。
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