Goudeau A, Coursaget P, Drucker J, Maupas P, Borie P, Benhamou J P
Med Microbiol Immunol. 1978 Nov 17;166(1-4):231-7. doi: 10.1007/BF02121155.
Numerous cases of chronic hepatitis have been shown to be closely associated with persistent infection with hepatitis B virus (HBV). A group of 100 patients suffering from chronic active hepatitis (CAH) was investigated for HBV serologic markers. Of these, 35 patients were HbsAg-positive; in 26 HBsAg-negative subjects, anti-HBc were detected using counterimmune electrophoresis and complement-fixation tests. These data suggest that chronic liver disease in patients who were only anti-HBc-positive might be related to persistent infection with hepatitis B virus. Epidemiological clinical and histopathological data were different when we compared CAH patients who were HBsAg-negative, but anti-HBc-positive, with HBsAg-positive CAH patients. A sequence is proposed leading from HBsAg-positive to HBsAg-negative CAH, cirrhosis, and hepatoma in temperate areas, according to a model similar to the one described in intertropical Africa.
大量慢性肝炎病例已被证明与乙肝病毒（HBV）持续感染密切相关。对一组100例慢性活动性肝炎（CAH）患者进行了乙肝病毒血清学标志物检测。其中，35例患者HBsAg阳性；在26例HBsAg阴性患者中，采用对流免疫电泳和补体结合试验检测到抗HBc。这些数据表明，仅抗HBc阳性患者的慢性肝病可能与乙肝病毒持续感染有关。当我们将HBsAg阴性但抗HBc阳性的CAH患者与HBsAg阳性的CAH患者进行比较时，流行病学、临床和组织病理学数据有所不同。根据与热带非洲描述的模型相似的模型，提出了一个在温带地区从HBsAg阳性的CAH到HBsAg阴性的CAH、肝硬化和肝癌的发展序列。
