Kotrasová Veronika, Keresztesová Barbora, Ondrovičová Gabriela, Bauer Jacob A, Havalová Henrieta, Pevala Vladimír, Kutejová Eva, Kunová Nina
Institute of Molecular Biology, Slovak Academy of Sciences, Dúbravská Cesta 21, 845 51 Bratislava, Slovakia.
First Faculty of Medicine, Institute of Biology and Medical Genetics, Charles University, 128 00 Prague, Czech Republic.
Life (Basel). 2021 Jan 23;11(2):82. doi: 10.3390/life11020082.
The major role of mitochondria is to provide cells with energy, but no less important are their roles in responding to various stress factors and the metabolic changes and pathological processes that might occur inside and outside the cells. The post-translational modification of proteins is a fast and efficient way for cells to adapt to ever changing conditions. Phosphorylation is a post-translational modification that signals these changes and propagates these signals throughout the whole cell, but it also changes the structure, function and interaction of individual proteins. In this review, we summarize the influence of kinases, the proteins responsible for phosphorylation, on mitochondrial biogenesis under various cellular conditions. We focus on their role in keeping mitochondria fully functional in healthy cells and also on the changes in mitochondrial structure and function that occur in pathological processes arising from the phosphorylation of mitochondrial proteins.
线粒体的主要作用是为细胞提供能量，但其在应对各种应激因素以及细胞内外可能发生的代谢变化和病理过程中的作用同样重要。蛋白质的翻译后修饰是细胞适应不断变化的条件的一种快速而有效的方式。磷酸化是一种翻译后修饰，它标志着这些变化并将这些信号在整个细胞中传播，但它也会改变单个蛋白质的结构、功能和相互作用。在本综述中，我们总结了负责磷酸化的激酶在各种细胞条件下对线粒体生物发生的影响。我们关注它们在使线粒体在健康细胞中保持完全功能方面的作用，以及线粒体蛋白质磷酸化所引发的病理过程中发生的线粒体结构和功能变化。
