Tunca J, Palmer A, Nahmias A, Mihalik K, Naib Z, London W, Sever J
Obstet Gynecol. 1978 Nov;52(5):634-9.
A total of 410 colposcopic examinations were performed on 188 female cebus monkeys that were under study to determine the oncogenic potential of herpes simplex virus type 2 in this genus. A split-cone vaginal speculum was developed that permitted good observation of the vaginal cervix in the cebus monkey. The cervical anatomy of cebus monkeys was found to differ from that of humans in that the surface of the animal cervix was more papilliform, with thinner squamous epithelium, and the squamocolumnar junction lay within the endocervical canal. Therefore, the ability to detect abnormalities in the cervical epithelium by colposcopic examination in the cebus monkey was restricted to vascular changes in the squamous epithelium. After 100 examinations, several vascular patterns were distinguishable and interpretations of these patterns were compared with cytologic findings on the same animals. Findings by both cytology and colposcopy were mild in nature; no carcinoma was detected. Colposcopic and cytologic findings correlated at a level of 84%. More abnormalities were detected with colposcopy than with use of cytologic techniques.
对188只雌性卷尾猴进行了共计410次阴道镜检查，以研究2型单纯疱疹病毒在该属动物中的致癌潜力。开发了一种分体锥形阴道窥器，以便能很好地观察卷尾猴的阴道宫颈。发现卷尾猴的宫颈解剖结构与人类不同，其宫颈表面更呈乳头状，鳞状上皮更薄，鳞柱交界位于宫颈管内。因此，通过阴道镜检查在卷尾猴中检测宫颈上皮异常的能力仅限于鳞状上皮的血管变化。在100次检查后，可区分出几种血管模式，并将这些模式的解读与同一动物的细胞学检查结果进行比较。细胞学和阴道镜检查结果本质上都较为轻微；未检测到癌症。阴道镜检查和细胞学检查结果的相关性为84%。阴道镜检查比细胞学技术检测到的异常更多。
